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腋窝淋巴结清扫术后腋窝短期与长期引流的前瞻性随机研究。

Short versus long-term postoperative drainage of the axilla after axillary lymph node dissection. A prospective randomized study.

作者信息

Baas-Vrancken Peeters Marie-Jeanne T F D, Kluit Ariane B, Merkus Jos W S, Breslau Paul J

机构信息

Department of Surgery, Haga Hospital, The Hague, The Netherlands.

出版信息

Breast Cancer Res Treat. 2005 Oct;93(3):271-5. doi: 10.1007/s10549-005-5348-7.

Abstract

BACKGROUND

Axillary lymph node dissection (ALND) is a standard procedure in the treatment of breast cancer. Current practice following ALND involves several days of drainage of the axilla to reduce the formation of seroma. The aim of this study is to investigate the feasibility of 24 h drainage.

STUDY DESIGN

A prospective randomized trial was performed comparing 24 h drainage to long-term drainage. The primary outcome measure was duration of hospital stay. Formation of seroma and wound related complications were secondary outcome measures.

RESULTS

Fifty patients were randomised to the 24 h drainage group and 50 patients to the long-term drainage group. 24 h drainage was associated with a shorter hospital stay (2.5 versus 4.6 days, p < 0.001). Seroma aspiration was required in 76% of the patients after 24 h drainage and in 64% after long-term drainage (p = 0.19). The number of wound related complications was higher after long-term drainage (13 versus 9, p = 0.33). Infectious complications were seen in 11 patients after long-term drainage versus 6 after 24 h drainage (p = 0.18).

CONCLUSION

These results indicate that 24 h drainage following ALND is feasible and facilitates early hospital discharge. Furthermore, 24 h drainage is not associated with excess wound related complications compared to long-term drainage.

摘要

背景

腋窝淋巴结清扫术(ALND)是乳腺癌治疗的标准术式。目前ALND术后的做法是对腋窝进行数天引流以减少血清肿的形成。本研究的目的是探讨24小时引流的可行性。

研究设计

进行了一项前瞻性随机试验,比较24小时引流与长期引流。主要结局指标是住院时间。血清肿的形成和伤口相关并发症是次要结局指标。

结果

50例患者被随机分配至24小时引流组,50例患者被分配至长期引流组。24小时引流与较短的住院时间相关(2.5天对4.6天,p<0.001)。24小时引流后76%的患者需要进行血清肿抽吸,长期引流后这一比例为64%(p=0.19)。长期引流后伤口相关并发症的数量更多(13例对9例,p=0.33)。长期引流后11例患者出现感染性并发症,24小时引流后为6例(p=0.18)。

结论

这些结果表明,ALND术后24小时引流是可行的,并有助于早期出院。此外,与长期引流相比,24小时引流不会增加伤口相关并发症。

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