Bonnema J, van Geel A N, Ligtenstein D A, Schmitz P I, Wiggers T
Department of Surgical Oncology, University Hospital Rotterdam/Daniel den Hoed Cancer Center, Rotterdam, The Netherlands.
Am J Surg. 1997 Feb;173(2):76-9. doi: 10.1016/S0002-9610(96)00416-3.
The influence of negative pressure on fluid production and complication rates after axillary dissection for breast cancer was studied in a prospective randomized trial. Patients were randomized for either a high or a low vacuum drainage system. Drainage volumes and complication rates were recorded.
No statistically significant differences were found between the low vacuum group (n = 68) and the high vacuum group (n = 73) in volume (728 ml versus 780 ml) and duration (9.5 days versus 10 days) of seroma production, number of wound complications (5 versus 6), or infections (3 versus 2). There was a significant positive relationship between body mass index and seroma production, independent of the drainage system (P = 0.002). The drainage volume of the separately drained breast wound after mastectomy and lumpectomy was larger for the high vacuum system (55 ml versus 100 ml, P = 0.02). Vacuum loss was more frequent in the high vacuum drain group (11 versus 2, P = 0.01), where as leakage around the drain occurred more often in the low vacuum group (18 versus 6, P = 0.004).
There are no differences in axillary fluid production or wound complication rates after axillary dissection and subsequent drainage between high and low vacuum drainage systems.
在一项前瞻性随机试验中，研究了负压对乳腺癌腋窝清扫术后液体生成及并发症发生率的影响。患者被随机分为高真空引流系统组或低真空引流系统组。记录引流量及并发症发生率。
低真空组（n = 68）和高真空组（n = 73）在血清肿生成量（728毫升对780毫升）、持续时间（9.5天对10天）、伤口并发症数量（5例对6例）或感染情况（3例对2例）方面，均未发现统计学上的显著差异。体重指数与血清肿生成之间存在显著正相关，且与引流系统无关（P = 0.002）。对于乳房切除术后和肿块切除术后单独引流的乳房伤口，高真空系统的引流量更大（55毫升对100毫升，P = 0.02）。高真空引流组的真空损失更频繁（11次对2次，P = 0.01），而低真空组引流周围的渗漏更常见（18次对6次，P = 0.004）。
高真空引流系统和低真空引流系统在腋窝清扫及后续引流后，腋窝液体生成或伤口并发症发生率并无差异。
