聚合物胶束包封钪作为用于高通量有机合成的聚合物负载催化剂。

Polymer-micelle incarcerated scandium as a polymer-supported catalyst for high-throughput organic synthesis.

作者信息

Takeuchi Masahiro, Akiyama Ryo, Kobayashi Shu

机构信息

Graduate School of Pharmaceutical Sciences, The University of Tokyo, The HFRE Division, ERATO, Japan Science and Technology Agency, Tokyo 113-0033, Japan.

出版信息

J Am Chem Soc. 2005 Sep 28;127(38):13096-7. doi: 10.1021/ja053176f.

DOI:10.1021/ja053176f

PMID:16173708

Abstract

A novel immobilization technique for Sc(OTf)3, a polymer-micelle incarcerated (PMI) method, has been developed. PMI Sc(OTf)3 is highly active in several fundamental carbon-carbon bond-forming reactions. The catalyst is recovered quantitatively by simple filtration and reused several times without loss of catalytic activity, and no Sc leaching was observed in all reactions (<0.1 ppm). In addition, several solvents are available, and these aspects are suitable for high-throughput organic synthesis (HTOS). To the best of our knowledge, this is the first example of immobilization of Lewis acids utilizing polymer micelles.

摘要

一种用于三氟甲磺酸钪（Sc(OTf)3）的新型固定化技术——聚合物胶束包封（PMI）法已被开发出来。PMI Sc(OTf)3在几种基本的碳-碳键形成反应中具有高活性。通过简单过滤可定量回收催化剂，并可重复使用多次而不损失催化活性，且在所有反应中均未观察到钪的浸出（<0.1 ppm）。此外，有几种溶剂可供使用，这些方面适用于高通量有机合成（HTOS）。据我们所知，这是利用聚合物胶束固定路易斯酸的首个实例。