Riekkinen P, Riekkinen M, Valjakka A, Riekkinen P, Sirviö J
Department of Neurology, University of Kuopio, Finland.
Brain Res. 1992 Jan 20;570(1-2):293-9. doi: 10.1016/0006-8993(92)90593-x.
The present study examines the effects of noradrenergic lesions (either DSP-4 i.p. or 6-hydroxydopamine (6-OHDA) into the dorsal noradrenergic bundle on biochemical (noradrenaline (NA), dopamine (DA), serotonin (5-HT) and choline acetyltransferase (ChAT) activity) and cortical EEG (quantitative EEG (qEEG) and high-voltage spindle (HVS)) activity in young and aged rats. Near complete 6-OHDA NA lesions, but not partial DSP-4 NA lesions, increased HVS activity in young rats. DSP-4 and 6-OHDA lesions produced no significant changes in the 5-HT or DA levels or in the ChAT activity in young rats. In some of the aged rats, DSP-4 produced similar biochemical and HVS effects, as it induced in young rats. In the remainder of the aged rats, NA levels were greatly and 5-HT levels slightly decreased. DA levels and ChAT activity were unaltered in either set of aged rats. HVS activity was increased only in that group of aged rats with the greatly lowered NA content. These results suggest that: (1) some of the aged rats are more sensitive to DSP-4 treatment than young adult rats; and (2) NA depletions have to be complete to produce an increase in HVS activity in young and aged rats.
本研究考察了去甲肾上腺素能损伤（腹腔注射DSP-4或向背侧去甲肾上腺素能束注射6-羟基多巴胺（6-OHDA））对年轻和老年大鼠生化指标（去甲肾上腺素（NA）、多巴胺（DA）、5-羟色胺（5-HT）和胆碱乙酰转移酶（ChAT）活性）以及皮质脑电图（定量脑电图（qEEG）和高压纺锤波（HVS））活性的影响。几乎完全的6-OHDA去甲肾上腺素损伤（而非部分DSP-4去甲肾上腺素损伤）增加了年轻大鼠的HVS活性。DSP-4和6-OHDA损伤对年轻大鼠的5-HT或DA水平以及ChAT活性未产生显著变化。在一些老年大鼠中，DSP-4产生了与年轻大鼠中相似的生化和HVS效应。在其余老年大鼠中，NA水平大幅下降，5-HT水平略有下降。两组老年大鼠的DA水平和ChAT活性均未改变。仅在NA含量大幅降低的老年大鼠组中HVS活性增加。这些结果表明：（1）一些老年大鼠比年轻成年大鼠对DSP-4治疗更敏感；（2）去甲肾上腺素耗竭必须完全才能使年轻和老年大鼠的HVS活性增加。
