Svetec Nicolas, Houot Benjamin, Ferveur Jean-François
Unité de Recherche 5548 Associée au Centre National de la Recherche Scientifique, Faculté des Sciences, Université de Bourgogne, 6, Bd Gabriel, 21000 Dijon, France.
Genet Res. 2005 Jun;85(3):183-93. doi: 10.1017/S0016672305007536.
Behaviour depends (a) on genes that specify the neural and non-neural elements involved in the perception of and responses to sensory stimuli and (b) on experience that can modulate the fine development of these elements. We exposed transgenic and control Drosophila melanogaster males, and their hybrids, to male siblings during adult development and measured the contribution of genes and of experience to their courtship behaviour. The transgene CheB42a specifically targets male gustatory sensillae and alters the perception of male inhibitory pheromones which leads to frequent male-male interactions. The age at which social experience occurred and the genotype of tester males induced a variable effect on the intensity of male homo- and heterosexual courtship. The strong interaction between the effects of genes and of social experience reveals the plasticity of the apparently stereotyped elements involved in male courtship behaviour. Finally, a high intensity of homosexual courtship was found only in males that simultaneously carried a mutation in their white gene and the CheB42a transgene.
(a) 那些指定参与感觉刺激感知和反应的神经及非神经元件的基因，以及 (b) 能够调节这些元件精细发育的经验。我们在成年发育期间将转基因和对照黑腹果蝇雄性及其杂种与雄性同胞放在一起，并测量基因和经验对它们求偶行为的影响。转基因CheB42a专门针对雄性味觉感受器，并改变对雄性抑制性信息素的感知，这导致频繁的雄性与雄性之间的互动。社交经验发生的年龄以及测试雄性的基因型对雄性同性和异性求偶强度产生了可变影响。基因效应与社交经验效应之间的强烈相互作用揭示了雄性求偶行为中明显刻板元件的可塑性。最后，仅在其白色基因和CheB42a转基因同时发生突变的雄性中发现了高强度的同性求偶行为。
