Velozo C A, Almli C R
Department of Occupational Therapy, College of Associated Health Professions, University of Illinois, Chicago 60612.
Brain Res Bull. 1992 Apr;28(4):503-11. doi: 10.1016/0361-9230(92)90096-g.
Lateral hypothalamic area (LHA) single unit activity (extracellular) was studied in response to electrical stimulation of the olfactory bulb (OB) or sciatic nerve in adult albino rats (n = 39) anesthetized with dialurethane. Olfactory stimulation resulted in a greater proportion of LHA units showing inhibitory rather than excitatory responses, while sciatic nerve stimulation resulted in similar proportions of units showing inhibitory and excitatory responses. Of the 76 LHA units tested with both OB and sciatic nerve stimulation, 36% responded to both stimulation sites, 18% responded only to OB stimulation, 26% responded only to sciatic nerve stimulation, and 20% were unresponsive to either stimulation. The locations of responsive units were diffuse throughout the LHA sampled. The response characteristics of LHA neurons to external sensory stimulation are consistent with the anatomy and putative integrative functions of this brain region.
在使用双氨基甲酸乙酯麻醉的成年白化大鼠（n = 39）中，研究了外侧下丘脑区域（LHA）的单单位活动（细胞外）对嗅球（OB）或坐骨神经电刺激的反应。嗅觉刺激导致LHA单位中表现出抑制性反应而非兴奋性反应的比例更高，而坐骨神经刺激导致表现出抑制性和兴奋性反应的单位比例相似。在同时接受OB和坐骨神经刺激测试的76个LHA单位中，36%对两个刺激部位都有反应，18%仅对OB刺激有反应，26%仅对坐骨神经刺激有反应，20%对两种刺激均无反应。有反应的单位位置在整个采样的LHA中分布广泛。LHA神经元对外界感觉刺激的反应特性与该脑区的解剖结构和假定的整合功能一致。
