Farragher Rachel A, Laffey John G
Department of Anaesthesia, University College Hospital, and Clinical Sciences Institute, National University of Ireland, Galway, Ireland.
Neurocrit Care. 2005;3(2):99-106. doi: 10.1385/NCC:3:2:099.
Brain death is a concept used in situations in which life-support equipment obscures the conventional cardiopulmonary criteria of death, and it is legally recognized in most countries worldwide. Brain death during pregnancy is an occasional and tragic occurrence. The mother and fetus are two distinct organisms, and the death of the mother mandates consideration of the well-being of the fetus. Where maternal brain death occurs after the onset of fetal viability, the benefits of prolonging the pregnancy to allow further fetal maturation must be weighed against the risks of continued time in utero, and preparations must be made to facilitate urgent cesarean section and fetal resuscitation at short notice. Where the fetus is nonviable, one must consider whether continuation of maternal organ supportive measures in an attempt to attain fetal viability is appropriate, or whether it constitutes futile care. Although the gestational age of the fetus is central to resolving this issue, there is no clear upper physiological limit to the prolongation of somatic function after brain death. Furthermore, medical experience regarding prolonged somatic support is limited and can be considered experimental therapy. This article explores these issues by considering the concept of brain death and how it relates to somatic death. The current limits of fetal viability are then discussed. The complex ethical issues and the important variations in the legal context worldwide are considered. Finally, the likelihood of successfully sustaining maternal somatic function for prolonged periods and the medical and obstetric issues that are likely to arise are examined.
脑死亡是在生命维持设备掩盖了传统心肺死亡标准的情况下所使用的概念,并且在世界上大多数国家都得到了法律认可。妊娠期脑死亡是一种偶发的悲剧事件。母亲和胎儿是两个不同的生物体,母亲的死亡必须考虑胎儿的福祉。如果在胎儿具有存活能力之后发生母亲脑死亡,延长妊娠以促进胎儿进一步成熟的益处必须与胎儿继续留在子宫内的风险相权衡,并且必须做好准备以便在短时间内实施紧急剖宫产和胎儿复苏。如果胎儿没有存活能力,就必须考虑继续采取母亲器官支持措施以试图实现胎儿存活是否合适,或者这是否构成无效治疗。虽然胎儿的孕周对于解决这个问题至关重要,但脑死亡后躯体功能延长并没有明确的生理上限。此外,关于长期躯体支持的医学经验有限,可以被视为实验性治疗。本文通过考虑脑死亡的概念及其与躯体死亡的关系来探讨这些问题。随后讨论了当前胎儿存活能力的限度。还考虑了复杂的伦理问题以及全球法律背景下的重要差异。最后,研究了长时间成功维持母亲躯体功能的可能性以及可能出现的医学和产科问题。