用ε-氨基己酸治疗急性脑出血：一项初步研究。
Treatment of acute intracerebral hemorrhage with epsilon-aminocaproic acid: a pilot study.
作者信息
Piriyawat Paisith, Morgenstern Lewis B, Yawn David H, Hall Christiana E, Grotta James C
机构信息
Stroke Program, Department of Neurology, University of Texas at Houston, Houston, TX 77030, USA.
出版信息
Neurocrit Care. 2004;1(1):47-51. doi: 10.1385/ncc:1:1:47.
INTRODUCTION
Up to 40% of primary intracerebral hemorrhages (ICHs) expand within the first 24 hours (natural history). The authors aimed to study the safety and preliminary efficacy of epsilon-aminocaproic acid (EACA) in halting ICH enlargement.
METHODS
Consecutive patients with hematoma volumes ranging from 5 to 80 mL were recruited within 12 hours of ICH onset. A total of 5 g EACA was infused during 1 hour and then 1 g/hour for 23 hours. Hematoma volume was compared on baseline, and 24-48-hour brain imaging. Consecutive untreated patients underwent the same imaging protocol.
RESULTS
Three of the first five patients treated had HE>33% of their baseline volume. HE occurred in two of the nine untreated patients. The 80% confidence interval for HE in the treated patients was 32-88%. No thrombotic or other serious adverse events were attributed to EACA.
CONCLUSION
It is unlikely that the rate of HE in patients given EACA within 12 hours of ICH is less than the natural history rate, although this treatment appears to be safe.
引言
高达40%的原发性脑出血（ICH）在最初24小时内会扩大（自然病程）。作者旨在研究ε-氨基己酸（EACA）在阻止ICH扩大方面的安全性和初步疗效。
方法
在ICH发病12小时内招募血肿体积为5至80毫升的连续患者。在1小时内输注5克EACA，然后以1克/小时的速度输注23小时。比较基线时以及24至48小时脑部成像时的血肿体积。连续的未治疗患者接受相同的成像方案。
结果
最初治疗的五名患者中有三名血肿扩大（HE）超过其基线体积的33%。九名未治疗患者中有两名发生HE。治疗患者中HE的80%置信区间为32 - 88%。没有血栓形成或其他严重不良事件归因于EACA。
结论
尽管这种治疗似乎是安全的，但在ICH发病12小时内给予EACA的患者中，HE发生率不太可能低于自然病程发生率。
Zotero 插件