Kozora Elizabeth, Arciniegas David B, Filley Christopher M, Ellison Misoo C, West Sterling G, Brown Mark S, Simon Jack H
National Jewish Medical and Research Center, Denver, Colorado 80206, USA.
Cogn Behav Neurol. 2005 Sep;18(3):159-62. doi: 10.1097/01.wnn.0000181543.05064.4b.
To correlate cognitive dysfunction with structural and neurometabolic brain findings in patients with non-neuropsychiatric systemic lupus erythematosus (non-NPSLE).
Over 25% of non-NPSLE patients have cognitive dysfunction, but the cerebral basis of this observation is not well understood.
Seven patients with non-NPSLE and seven control subjects were given a series of neuropsychological tests and neuroimaging with magnetic resonance imaging and magnetic resonance spectroscopy. Analyses of cognitive function and structural and neurometabolic measures of the brain were performed.
Compared with controls, the non-NPSLE patients were significantly impaired on a global cognitive impairment index (CII). No significant differences between the groups were found in choline/creatine (Ch/Cr), N-acetylaspartic acid/Cr, or hippocampal volumes. Ch/Cr was highly associated with CII across the sample.
This is the first study to correlate cognitive impairment with an increase in Ch/Cr ratio among patients with SLE. These results, although preliminary, suggest that changes in cerebral white matter may be important in determining the subtle cognitive impairment that may occur in patients with SLE, even in the absence of neuropsychiatric symptoms.
探讨非神经精神性系统性红斑狼疮（non-NPSLE）患者认知功能障碍与脑结构及神经代谢改变之间的相关性。
超过25%的non-NPSLE患者存在认知功能障碍，但这种现象的脑基础尚不清楚。
对7例non-NPSLE患者和7例对照者进行了一系列神经心理学测试，并采用磁共振成像和磁共振波谱进行神经影像学检查。对认知功能以及脑结构和神经代谢指标进行了分析。
与对照组相比，non-NPSLE患者的整体认知障碍指数（CII）显著受损。两组在胆碱/肌酸（Ch/Cr）、N-乙酰天门冬氨酸/肌酸或海马体积方面未发现显著差异。在整个样本中，Ch/Cr与CII高度相关。
这是第一项将SLE患者认知障碍与Ch/Cr比值升高相关联的研究。这些结果虽然初步，但表明脑白质改变可能在决定SLE患者即使无神经精神症状时也可能出现的轻微认知障碍中起重要作用。
