Vergara J, Repetto G, Alvarez J
Escuela de Medicina, Facultad de Ciencias Biológicas, P. Universidad Católica, Santiago, Chile.
J Submicrosc Cytol Pathol. 1992 Jan;24(1):129-34.
In infants with spastic disorders and with congenital dysplasia of the hip (CDH), the microtubular content of nonmedullated and myelinated fibres of the anterior obturator nerves was studied with the electron microscope. In CDH infants, the microtubular content of nonmedullated and myelinated fibres was similar to values reported for experimental animals. In spastic patients, the microtubular content of nonmedullated fibres was similar to that found in CDH patients while the microtubular densities of 3- and 10-microns myelinated fibres were 37.5 and 16.7 microtubules/micron2, respectively, or 100% and 43% greater than corresponding values of CDH patients. We propose that the high firing rate determines the abnormally high microtubular content of myelinated axons supplying spastic muscles.
在患有痉挛性疾病和先天性髋关节发育不良（CDH）的婴儿中，使用电子显微镜研究了闭孔前神经的无髓鞘和有髓鞘纤维的微管含量。在患有CDH的婴儿中，无髓鞘和有髓鞘纤维的微管含量与实验动物报告的值相似。在痉挛性患者中，无髓鞘纤维的微管含量与CDH患者中发现的相似，而3微米和10微米有髓鞘纤维的微管密度分别为37.5和16.7微管/微米²，比CDH患者的相应值分别高100%和43%。我们认为，高放电率决定了供应痉挛性肌肉的有髓轴突中异常高的微管含量。
