Kovácik V, Kovác P, Grützmacher H F
Institute of Chemistry, Slovak Academy of Sciences, Bratislava, Czechoslovakia.
Carbohydr Res. 1992 Mar 30;226(2):189-96. doi: 10.1016/0008-6215(92)84066-2.
Fully acetylated methyl x-deoxy-x-fluoro-alpha-D-glucopyranosides have been studied using electron impact and ammonia chemical ionisation mass spectrometry. Mass analysed metastable ion kinetic energy spectroscopy (MIKE), collisional activation (CID), and accelerated voltage scanning have been used to evaluate complete fragmentation schemes. Characteristic differences in the fragmentation of positional isomers were noted on analysis of the spectra, and these make it possible to determine the location of fluorine in the molecules studied. Collisionally activated fragmentation of [M-OCH3]+ ions, produced by electron impact, provides an alternative method for localisation of the fluorine atoms. To the contrary, MIKE and CID spectra of [M + NH4]+ cluster ions produced by chemical ionisation did not afford such structural information.
已使用电子轰击和氨化学电离质谱法对全乙酰化甲基 -x- 脱氧 -x- 氟 -α-D- 吡喃葡萄糖苷进行了研究。采用质量分析亚稳离子动能谱（MIKE）、碰撞活化（CID）和加速电压扫描来评估完整的裂解方案。在对光谱进行分析时，注意到位置异构体裂解的特征差异，这些差异使得确定所研究分子中氟的位置成为可能。电子轰击产生的 [M - OCH₃]+ 离子的碰撞活化裂解为氟原子的定位提供了另一种方法。相反，化学电离产生的 [M + NH₄]+ 簇离子的 MIKE 和 CID 光谱并未提供此类结构信息。
