烟曲霉体外生长速率与体内毒力之间的相关性
Correlation between in vitro growth rate and in vivo virulence in Aspergillus fumigatus.
作者信息
Paisley Derek, Robson Geoffrey D, Denning David W
机构信息
Clinical Sciences Building, Hope Hospital, Salford, UK.
出版信息
Med Mycol. 2005 Aug;43(5):397-401. doi: 10.1080/13693780400005866.
PMID:16178367
Abstract
We describe a kinetic microbroth method of measuring the growth rate of Aspergillus fumigatus spectrophotometrically. Using this method, growth rates were determined for nine A. fumigatus isolates for which an LD90 value in immunosuppressed CD-1 mice had previously been obtained. Comparison of the growth rates and LD90 values of these isolates suggests that a correlation exists between the two parameters.
摘要
我们描述了一种通过分光光度法测量烟曲霉生长速率的动力学微量肉汤法。使用该方法，测定了9株烟曲霉分离株的生长速率，这些分离株此前已获得免疫抑制CD-1小鼠的半数致死剂量（LD90）值。对这些分离株的生长速率和LD90值进行比较表明，这两个参数之间存在相关性。
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