钯催化炔酯的羰基化反应生成γ-亚烷基-α,β-不饱和γ-内酯。
Palladium-catalyzed carbonylation of yne esters leading to gamma-alkylidene alpha,beta-unsaturated gamma-lactones.
作者信息
Harada Yasuyuki, Fukumoto Yoshiya, Chatani Naoto
机构信息
Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
出版信息
Org Lett. 2005 Sep 29;7(20):4385-7. doi: 10.1021/ol0514956.
PMID:16178539
Abstract
[reaction: see text] The reaction of yne esters with carbon monoxide (1 atm) in the presence of palladium complexes gives bicyclic unsaturated lactone derivatives in good to high yields. The 2-pyridinyloxy group is a good leaving group among leaving groups examined.
摘要
[反应：见正文] 在钯配合物存在下，炔酯与一氧化碳（1个大气压）反应，以良好至高收率得到双环不饱和内酯衍生物。在所研究的离去基团中，2-吡啶氧基是一个良好的离去基团。
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