Li Yu, Yu Zhengkun, Alper Howard
Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario, Canada K1N 6N5.
Org Lett. 2007 Apr 26;9(9):1647-9. doi: 10.1021/ol070231b. Epub 2007 Mar 31.
[reaction: see text] A new, efficient ionic liquid based synthetic procedure was developed for the preparation of highly substituted endocyclic enol lactones via the carbonylation coupling reactions of alkynes and 1,3-diketones in ionic liquid. The reactions proceeded in excellent regioselectivity and in reasonably good yields. The catalyst system can be recycled five times with only modest loss of its catalytic activity.
[反应：见正文] 开发了一种基于离子液体的新型高效合成方法，用于通过炔烃和1,3 - 二酮在离子液体中的羰基化偶联反应制备高度取代的内环烯醇内酯。反应具有出色的区域选择性，产率也相当可观。该催化体系可循环使用五次，其催化活性仅有适度损失。
