Kim Joon Young, Livinghouse Tom
Department of Chemistry, Montana State University, Bozeman, Montana 59717, USA.
Org Lett. 2005 Sep 29;7(20):4391-3. doi: 10.1021/ol051574h.
[reaction: see text] Neutral scandium amido complexes are viable catalysts for intramolecular alkene hydroamination. Catalytic activity is strongly coupled to the electronic character of the Sc(III) ligand environment with chelating diamide coordination providing a precatalyst possessing substantially improved activity and superb distereoselectivity in the synthesis of trans-2,5-disubstituted pyrrolidines.
[反应：见正文] 中性钪酰胺配合物是分子内烯烃氢胺化反应的可行催化剂。催化活性与Sc(III)配体环境的电子特性密切相关，螯合二酰胺配位提供了一种前催化剂，该前催化剂在反式-2,5-二取代吡咯烷的合成中具有显著提高的活性和优异的非对映选择性。
