二叔丁基硅烯导向的4-甲基伞形酮基T抗原的α-选择性合成。
Di-tert-butylsilylene-directed alpha-selective synthesis of 4-methylumbelliferyl T-antigen.
作者信息
Imamura Akihiro, Ando Hiromune, Ishida Hideharu, Kiso Makoto
机构信息
Department of Applied Bioorganic Chemistry, Gifu University, Gifu 501-1193, Japan.
出版信息
Org Lett. 2005 Sep 29;7(20):4415-8. doi: 10.1021/ol051592z.
PMID:16178547
Abstract
[reaction: see text] We have succeeded in the facile synthesis of 4-methylumbelliferyl T-antigen as a substrate for endo-alpha-N-acetylgalactosaminidase by exploiting the combination of the di-tert-butylsilylene effect and the Mitsunobu reaction.
摘要
[反应：见正文] 我们通过利用二叔丁基甲硅烷基效应和光延反应的组合，成功地简便合成了4-甲基伞形酮基T抗原作为内切α-N-乙酰半乳糖胺酶的底物。
Zotero 插件