Enantioselective direct aldol-Tishchenko reaction: access to chiral stereopentads.
作者信息
Rohr Kerstin, Herre Robert, Mahrwald Rainer
机构信息
Humboldt-Universität zu Berlin, Chemisches Institut, Brook-Taylor Str. 2, 12489 Berlin, Germany.
出版信息
Org Lett. 2005 Sep 29;7(20):4499-501. doi: 10.1021/ol0517675.
PMID:16178568
Abstract
[reaction: see text] The aldol-Tishchenko reaction of aromatic aldehydes in the presence of titanium(IV) tertbutoxide and amino alcohols is described. When used with cinchona alkaloids, stereopentads were isolated for the first time with a high degree of diastereo- and enantioselectivity.
摘要
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