Yourassowsky E, Van der Linden M P, Crokaert F
Department of Microbiology, Brugmann University Hospital, Brussels, Belgium.
Chemotherapy. 1992;38(1):7-13. doi: 10.1159/000238935.
A new method of data presentation that takes into account the relationship between growth and killing rate was used to evaluate the comparative in vitro bactericidal activity of cefpodoxime, cefuroxime, cefixime and an amoxicillin/clavulanic acid combination against Streptococcus pneumoniae and beta-lactamase-producing strains of Haemophilus influenzae and Moraxella catarrhalis. For each strain, the viable count decrease (log CFU/ml) after 6 h of exposure to different antibiotic concentrations was plotted against the viable count increase in the control culture, over the same time. Higher killing rates than those predicted by growth rates were defined as a positive balance; lower rates than those predicted by growth rates were defined as a negative balance. The activity of the 4 drugs against S. pneumoniae and M. catarrhalis was characterized by a positive balance. Conversely, the 3 cephalosporins showed a negative balance for H. influenzae.
一种考虑生长与杀灭率之间关系的数据呈现新方法，被用于评估头孢泊肟、头孢呋辛、头孢克肟以及阿莫西林/克拉维酸组合对肺炎链球菌、产β-内酰胺酶的流感嗜血杆菌和卡他莫拉菌的体外杀菌活性比较。对于每种菌株，将暴露于不同抗生素浓度6小时后的活菌数减少量（log CFU/ml）与同一时间对照培养物中的活菌数增加量进行绘图。高于生长率预测值的杀灭率被定义为正平衡；低于生长率预测值的率被定义为负平衡。这4种药物对肺炎链球菌和卡他莫拉菌的活性表现为正平衡。相反，3种头孢菌素对流感嗜血杆菌表现为负平衡。
