Kompella U B
UNMC College of Pharmacy, Omaha, NE 68198-6025, USA.
IDrugs. 1999 Jan;2(1):33-4.
At the 1998 annual meeting of the American Association of Pharmaceutical Scientists (AAPS) held in San Francisco, a symposium entitled 'Drug Delivery Applications of Supercritical Fluid Technology' was presented. Five speakers presented the advances made by their research groups in this area. Various approaches using supercritical fluids as solvents, antisolvents or mechanical agents were employed in forming particles or delivery systems of various drugs, including antibiotics, steroids and macromolecules. The particles obtained with this technology were small, free-flowing, easily wettable and have minimal surface charges. A coating unit employing supercritical CO2 to fluidize the substrates and to remove solvent has been reported. Nasal delivery of insulin was enhanced when the formulations were processed with supercritical CO2. Macromolecules such as insulin and trypsin dissolved in a carrier liquid could be incorporated in preformed microspheres upon supercritical fluid exposure. Thus supercritical fluid technology appears to be a promising new approach to process drugs and their dosage forms.
在1998年于旧金山举行的美国药物科学家协会（AAPS）年会上，举办了一场题为“超临界流体技术的药物递送应用”的研讨会。五位演讲者介绍了他们的研究小组在该领域取得的进展。使用超临界流体作为溶剂、抗溶剂或机械剂的各种方法被用于形成包括抗生素、类固醇和大分子在内的各种药物的颗粒或递送系统。用该技术获得的颗粒小、流动性好、易于润湿且表面电荷最小。据报道，有一种包衣装置采用超临界二氧化碳使底物流化并去除溶剂。当制剂用超临界二氧化碳处理时，胰岛素的鼻腔递送得到增强。溶解在载液中的胰岛素和胰蛋白酶等大分子在暴露于超临界流体时可被纳入预制微球中。因此，超临界流体技术似乎是一种有前途的加工药物及其剂型的新方法。
