Mishima Kenji
Department of Chemical Engineering, Advanced Materials Institute, Fukuoka University, Nanakuma, Jonan-ku, Fukuoka, Japan.
Adv Drug Deliv Rev. 2008 Feb 14;60(3):411-32. doi: 10.1016/j.addr.2007.02.003. Epub 2007 Oct 11.
Recent developments in biodegradable particle formation using supercritical fluids and dense gases have been reviewed with an emphasis on studies of micronizing and encapsulating poorly-soluble pharmaceuticals and gene. General review articles published in previous years have then been provided. A brief description of the operating principles of some types of particle formation processes is given. These include the rapid expansion of supercritical solutions (RESS), the particles from gas-saturated solution (PGSS) processes, the gas antisolvent process (GAS), and the supercritical antisolvent process (SAS). The papers have been reviewed under two groups, one involving the production of particles from pure biodegradable substances, and the other involving coating, capsule, and impregnation that contain active components, especially those that relate to pharmaceuticals. This review is a comprehensive review specifically focused on the formation of biodegradable particles for drug and gene delivery system using supercritical fluid and dense gas.
本文综述了利用超临界流体和稠密气体制备可生物降解颗粒的最新进展，重点关注难溶性药物和基因的微粉化及包封研究。随后提供了前几年发表的一般性综述文章。简要描述了某些类型颗粒形成过程的操作原理。这些过程包括超临界溶液快速膨胀法（RESS）、气体饱和溶液析出颗粒法（PGSS）、气体抗溶剂法（GAS）和超临界抗溶剂法（SAS）。论文分为两组进行综述，一组涉及由纯可生物降解物质制备颗粒，另一组涉及含有活性成分的包衣、胶囊和浸渍，特别是与药物相关的活性成分。本综述是一篇全面的综述，特别关注利用超临界流体和稠密气体形成用于药物和基因递送系统的可生物降解颗粒。
