Mayer Balázs, Doleschall Márton, Bender Balázs, Bartyik János, Bosze Zsuzsanna, Frenyó László V, Kacskovics Imre
Department of Physiology and Biochemistry, Faculty of Veterinary Science, Szent István University, PO Box 2, H-1400 Budapest, Hungary.
J Dairy Res. 2005;72 Spec No:107-12. doi: 10.1017/s0022029905001135.
In ruminants, protective immunoglobulins are transferred to the newborn via colostrum to mediate maternal immunity. There is a high selectivity in the transport of immunoglobulins from the maternal plasma across the mammary barrier into the colostrum, and only IgG1 is transferred in large amounts. We have recently analysed the expression of the neonatal Fc receptor (FcRn) in sheep mammary gland around parturition. Re-analysing this issue in bovine confirmed our previous data indicating that FcRn is homogeneously localized in the mammary gland acinar cells before parturition, however a remarkable difference was observed in the pattern after calving, where only the apical side of the cells was strongly stained. The presence of the FcRn in the acinar epithelial cells of the mammary gland and the obvious change in distribution before and after parturition indicate that FcRn plays an important role in the IgG transport during colostrum formation in ruminants.
在反刍动物中，保护性免疫球蛋白通过初乳传递给新生动物，以介导母体免疫。免疫球蛋白从母体血浆穿过乳腺屏障进入初乳的过程具有高度选择性，只有IgG1会大量转移。我们最近分析了分娩前后绵羊乳腺中新生Fc受体（FcRn）的表达。对牛的这一问题进行重新分析证实了我们之前的数据，表明FcRn在分娩前均匀地定位于乳腺腺泡细胞中，然而在产犊后的模式中观察到了显著差异，此时只有细胞的顶端侧被强烈染色。FcRn在乳腺腺泡上皮细胞中的存在以及分娩前后分布的明显变化表明，FcRn在反刍动物初乳形成过程中的IgG转运中起重要作用。
