紫胶醌B-D，来自海洋海绵紫胶漆斑菌的二吡咯醌。

Zyzzyanones B-D, dipyrroloquinones from the marine sponge Zyzzya fuliginosa.

作者信息

Utkina Natalia K, Makarchenko Aleksandra E, Denisenko Vladimir A

机构信息

Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 690022 Vladivostok, Russian Federation.

出版信息

J Nat Prod. 2005 Sep;68(9):1424-7. doi: 10.1021/np050154y.

DOI:10.1021/np050154y

PMID:16180829

Abstract

Zyzzyanones B, C, and D (2-4), three new dipyrroloquinones with a pyrrolo[3,2-f]indole-4,8(1H,7H)-dione skeleton, have been isolated from the Australian marine sponge Zyzzya fuliginosa. The known zyzzyanone A, makaluvamines C, E, G, H, and L, damirones A and B, 3,7-dimethylguanine, and 4-hydroxybenzoic acid were also isolated. The structures of the new compounds 2-4 were established by extensive NMR spectroscopic data. Compounds 2-4 showed moderate cytotoxic activity against mouse Ehrlich carcinoma cells (IC50 25 microg/mL).

摘要

从澳大利亚海洋海绵Zyzzya fuliginosa中分离出了Zyzzyanones B、C和D（2 - 4），这三种具有吡咯并[3,2 - f]吲哚 - 4,8(1H,7H)-二酮骨架的新型二吡咯醌。还分离出了已知的zyzzyanone A、makaluvamines C、E、G、H和L、damirones A和B、3,7 - 二甲基鸟嘌呤以及4 - 羟基苯甲酸。通过广泛的核磁共振光谱数据确定了新化合物2 - 4的结构。化合物2 - 4对小鼠艾氏癌细胞显示出中等细胞毒性活性（IC50为25微克/毫升）。