Discorhabdin W，首个二聚体Discorhabdin。

Discorhabdin W, the first dimeric discorhabdin.

作者信息

Lang Gerhard, Pinkert André, Blunt John W, Munro Murray H G

机构信息

Department of Chemistry, University of Canterbury, Private Bag 4800, Christchurch, New Zealand.

出版信息

J Nat Prod. 2005 Dec;68(12):1796-8. doi: 10.1021/np050333f.

DOI:10.1021/np050333f

PMID:16378380

Abstract

Discorhabdin W (1), isolated from a New Zealand Latrunculia sp. sponge, is a symmetrical dimer with potent in vitro activity against the P388 murine leukemia cell line. The structure and stereochemistry were assigned by using 1D- and 2D-NMR experiments and mass spectrometry. Discorhabdins B (2), D (3), G/I (4), and L (5) were also isolated from the same sponge.

摘要

从新西兰一种红海绵属（Latrunculia sp.）海绵中分离得到的Discorhabdin W (1) 是一种对称二聚体，对P388小鼠白血病细胞系具有强大的体外活性。通过一维和二维核磁共振实验以及质谱分析确定了其结构和立体化学。Discorhabdins B (2)、D (3)、G/I (4) 和L (5) 也从同一种海绵中分离得到。