Zhu Yan-bo, Wei Qing, Yuan Fei, Jin Xiao-long
Department of Pathology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China.
Zhonghua Bing Li Xue Za Zhi. 2005 May;34(5):279-82.
To investigate the clinicopathologic characteristics and differential diagnosis of myopericytoma.
Six cases of myopericytomas were analyzed by light microscopy and immunohistochemistry (LSAB detection method).
Tumors from 3 females and 3 males were found on the extremities and chest wall. The ages of these 6 patients ranged from 16 to 58 years. Histologically, all tumors were unencapsulated. The neoplastic cells were oval to spindle shaped with eosinophilic cytoplasm, had a myoid appearance and showd areas of concentric perivascular proliferation around lesional blood vessels which were present with focal myxoid stroma. Morphologically in some cases the tumor overlap myofibroma, hemangiopericytoma or glomus tumor. One tumor was located entirely within the lumen of a vein. In another case, the tumor displayed cellular pleomorphism, mitotic activity, necrosis should be diagnosed as malignant myopericytoma. The neoplastic cells were positive for SMA and negative for CD31, CD34, S-100, and CK.
Myopericytoma is composed of oval to spindle shaped myoid cells with a striking tendeny for concentric perivascular growth. These cells differentiate towards perivascular myoid cells or myopericytes. Extremely rare malignant myopericytoma exist.
探讨肌周细胞瘤的临床病理特征及鉴别诊断。
对6例肌周细胞瘤进行光镜及免疫组化（LSAB检测法）分析。
3例女性和3例男性患者的肿瘤分别位于四肢和胸壁。这6例患者年龄在16至58岁之间。组织学上，所有肿瘤均无包膜。肿瘤细胞呈椭圆形至梭形，胞质嗜酸性，具有肌样外观，在病变血管周围可见同心性血管周增生区域，并伴有局灶性黏液样间质。形态学上，部分病例的肿瘤与肌纤维瘤、血管外皮细胞瘤或血管球瘤有重叠。1例肿瘤完全位于静脉腔内。另1例肿瘤显示细胞多形性、有丝分裂活性及坏死，应诊断为恶性肌周细胞瘤。肿瘤细胞SMA阳性，CD31、CD34、S - 100及CK阴性。
肌周细胞瘤由椭圆形至梭形的肌样细胞组成，具有明显的同心性血管周生长倾向。这些细胞向血管周肌样细胞或肌周细胞分化。极罕见恶性肌周细胞瘤。
