Saucier D M, Corcoran M E
Department of Psychology, University of Victoria, BC, Canada.
Epilepsy Res. 1992 Apr;11(2):131-9. doi: 10.1016/0920-1211(92)90047-w.
We examined the characteristics of kindling of seizures with stimulation of the dorsal or ventral striatum in rats. Different groups of rats carried electrodes directed towards the nucleus accumbens or the head, middle, or tail of the caudate. Thresholds for afterdischarge (AD) were high at all sites, and stimulation often produced forced motor responses (motor responses that occurred during the stimulation and were not a consequence of kindling). Kindling at sites in the accumbens proceeded more slowly than at the sites in the caudate, which did not differ among themselves. The duration of accumbens seizures increased dramatically over the course of kindling, whereas the duration of caudate seizures remained relatively short and invariant. Although the kindled seizures resembled seizures kindled from limbic sites, they also contained aspects of seizures triggered from stimulation of the anterior neocortex. We conclude that striatal kindling comprises elements of both limbic and neocortical kindling.
我们研究了刺激大鼠背侧或腹侧纹状体引发癫痫发作的点燃特性。不同组的大鼠携带电极，电极分别指向伏隔核或尾状核的头部、中部或尾部。所有部位的后放电（AD）阈值都很高，并且刺激常常会产生强迫性运动反应（在刺激期间出现的运动反应，并非点燃的结果）。伏隔核部位的点燃过程比尾状核部位进行得更慢，而尾状核不同部位之间的点燃过程并无差异。在点燃过程中，伏隔核癫痫发作的持续时间显著增加，而尾状核癫痫发作的持续时间则相对较短且保持不变。尽管点燃性癫痫发作类似于从边缘系统部位点燃的癫痫发作，但它们也包含了从前额叶新皮质刺激引发的癫痫发作的一些特征。我们得出结论，纹状体点燃包含边缘系统和新皮质点燃的要素。
