Viana Adriana M, Campos Antonio Carlos de, Morlin Mayra T, Chin Verónica K L
Department of Oral and Maxillofacial Surgery, Universidade de São Paulo, São Paulo, Brazil.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005 Oct;100(4):415-9. doi: 10.1016/j.tripleo.2005.01.005.
The literature supports that systemic responses to injected vasoconstrictors depend on the volume and concentration administered, patient's age and health status, as well as site of injection. Thus, the influence of mandibular anesthesia technique on hemodynamic and plasma responses to epinephrine-containing local anesthetics was investigated.
Conventional or Gow-Gates anesthesia with 2% lidocaine and epinephrine, 1:100,000, was performed in 18 subjects who required third molar extraction. A control group of 9 subjects was submitted to conventional anesthesia with plain 3% mepivacaine. Blood pressure, heart rate, and plasma catecholamines were measured.
Analysis of variance showed that plasma epinephrine level after conventional lidocaine anesthesia was significantly elevated (P < .01), while there was no difference between the Gow-Gates and control groups. The hemodynamic parameters did not demonstrate correlation to the injection technique.
Presumably, there was less exogenous epinephrine absorption in the Gow-Gates technique than in the conventional mandibular anesthesia injection.
文献表明，对注射血管收缩剂的全身反应取决于给药的体积和浓度、患者的年龄和健康状况以及注射部位。因此，研究了下颌麻醉技术对含肾上腺素局部麻醉剂的血流动力学和血浆反应的影响。
对18名需要拔除第三磨牙的受试者进行了采用2%利多卡因和1:100,000肾上腺素的传统或Gow-Gates麻醉。9名受试者的对照组接受了单纯3%甲哌卡因的传统麻醉。测量了血压、心率和血浆儿茶酚胺。
方差分析显示，传统利多卡因麻醉后血浆肾上腺素水平显著升高（P <.01），而Gow-Gates组与对照组之间无差异。血流动力学参数与注射技术无关。
据推测，Gow-Gates技术中外源性肾上腺素的吸收比传统下颌麻醉注射少。
