Nikitin D O, Gavrilova L V
Gematol Transfuziol. 1992 Jan;37(1):15-7.
Subpopulations of rosette-forming cells were studied in lymphoid pools of peripheral blood and bone marrow of 24 children with acquired aplastic anemia, after a course of treatment with antilymphocytic globulin (ALG). After termination of the preparation transfusion a decrease in the levels of "active" T-lymphocytes and cells with C3-receptors was recorded. The levels of immature T-lymphocytes were found to be lowered four weeks after ALG-therapy, while other subpopulations remained within the normal. The lowering activity of immunogenesis in the bone marrow combined with hemopoietic recovery after the immunosuppressive therapy have evidenced a possible participation of immunologic mechanisms in the pathogenesis of acquired aplastic anemia in children.
对24例获得性再生障碍性贫血患儿外周血和骨髓淋巴样细胞库中形成玫瑰花结细胞的亚群进行了研究，这些患儿接受了抗淋巴细胞球蛋白（ALG）治疗。在终止制剂输注后，记录到“活性”T淋巴细胞和具有C3受体的细胞水平下降。发现ALG治疗四周后未成熟T淋巴细胞水平降低，而其他亚群仍在正常范围内。骨髓中免疫发生活性降低与免疫抑制治疗后的造血恢复相结合，证明免疫机制可能参与儿童获得性再生障碍性贫血的发病过程。
