Perini Rafael, Wallace John L, Ma Li
Mucosal Inflammation Research Group, University of Calgary, Calgary, Alberta, Canada T2N 4N1.
Dig Dis Sci. 2005 Oct;50 Suppl 1:S12-5. doi: 10.1007/s10620-005-2801-8.
Proteinase-activated receptors (PARs) are expressed on the surface of many cells, but those on the platelet have been among the most thoroughly characterized. PARs act as key receptors mediating the proaggregatory and pro-secretory effects of thrombin. In addition to contributing to hemostasis, platelets are increasingly being viewed as important contributors to healing and to tumor growth. This is attributable to the many pro- and anti-angiogenic factors that are stored within platelets, which can be released at the sites of injury and new vessel growth. In this paper, we review the importance of the platelet in gastric ulcer healing, the contribution of platelet-contained angiogenic factors to the healing of gastric ulcers, and the role of PARs in regulating the release of angiogenic factors from platelets. Taken together, our results suggest that PARs, including those expressed on platelets, are a rational therapeutic target for modulating healing processes and tumor growth.
蛋白酶激活受体(PARs)在许多细胞表面表达,但血小板上的PARs是研究最为透彻的。PARs作为关键受体,介导凝血酶的促聚集和促分泌作用。除了有助于止血外,血小板越来越被视为愈合和肿瘤生长的重要促成因素。这归因于血小板中储存的许多促血管生成和抗血管生成因子,它们可在损伤部位和新血管生长部位释放。在本文中,我们综述了血小板在胃溃疡愈合中的重要性、血小板所含血管生成因子对胃溃疡愈合的贡献,以及PARs在调节血小板血管生成因子释放中的作用。综上所述,我们的结果表明,包括血小板上表达的PARs在内,是调节愈合过程和肿瘤生长的合理治疗靶点。