Jeong Eunju, Yoo In Kyung, Cakir Ozlem Ozer, Kim Hee Kyung, Kim Won Hee, Hong Sung Pyo, Cho Joo Young
Digestive Disease Center, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
Alanya Alaaddin Keykubat University, School of Medicine Department of Gastroenterology and Hepatology, Antalya, Turkey.
Clin Endosc. 2019 Sep;52(5):472-478. doi: 10.5946/ce.2018.152. Epub 2019 May 17.
BACKGROUND/AIMS: Platelet-rich plasma (PRP) has been used for wound healing in various medical fields. The aim of this study was to evaluate the clinical efficacy and safety of local PRP injections after endoscopic submucosal dissection (ESD).
Patients were non-randomly divided into the following two groups: (1) control group in which patients were administered only an intravenous proton pump inhibitor (PPI), and (2) a study group in which patients were administered an intravenous PPI and a topical PRP injection. We assessed the reduction in the ulcer area and stage of the ulcer after the procedure (24 hours, 48 hours, and 28 days after endoscopic surgery).
We enrolled 7 study and 7 control patients. In the study group, the rate of ulcer reduction was 59% compared to 52% in the control group (p=0.372), 28 days after ESD. There were 5 patients in the S stage and 2 patients in the H stage in the study group compared to no patient in the S stage and 7 patients in the H stage in the control group (p=0.05), 28 days after ESD. There were no serious complications in either group.
The local injection of PRP is a safe and effective procedure for ulcer healing after ESD.
背景/目的：富血小板血浆（PRP）已被用于各个医学领域的伤口愈合。本研究的目的是评估内镜黏膜下剥离术（ESD）后局部注射PRP的临床疗效和安全性。
患者被非随机分为以下两组：（1）对照组，仅给予静脉质子泵抑制剂（PPI）；（2）研究组，给予静脉PPI和局部PRP注射。我们评估了术后（内镜手术后24小时、48小时和28天）溃疡面积的缩小和溃疡分期情况。
我们纳入了7例研究组患者和7例对照组患者。ESD术后28天，研究组溃疡缩小率为59%，对照组为52%（p = 0.372）。ESD术后28天，研究组有5例处于S期，2例处于H期，而对照组无患者处于S期，7例处于H期（p = 0.05）。两组均未出现严重并发症。
局部注射PRP是ESD术后溃疡愈合的一种安全有效的方法。
