糖尿病男性患前列腺癌的风险（西班牙）

Prostate cancer risk among men with diabetes mellitus (Spain).

作者信息

González-Pérez A, García Rodríguez L A

机构信息

Centro Español de Investigación Farmacoepidemiológica (CEIFE), Madrid, Spain.

出版信息

Cancer Causes Control. 2005 Nov;16(9):1055-8. doi: 10.1007/s10552-005-4705-5.

DOI:10.1007/s10552-005-4705-5

PMID:16184470

Abstract

OBJECTIVE

Observational studies have associated diabetes with a decreased risk of prostate cancer. We aimed to evaluate this association using the General Practitioner Research Database in the UK.

METHODS

Population based case-control study nested in a cohort.

RESULTS

We identified 2,183 incident cases of prostate cancer between January 1995 and December 2001. We found that diabetic patients had a decreased risk of prostate cancer (OR = 0.72; 95% CI: 0.59-0.87). This association was observed among treated diabetics (OR = 0.63; 95% CI: 0.50-0.80) but not among untreated diabetics (OR = 1.01; 95% CI: 0.73-1.40). Our results suggest that the observed reduced risk could be restricted to users of insulin or sulphonylureas.

CONCLUSION

Patients with diabetes have a decreased risk of prostate cancer. The role of antidiabetic treatment in this association warrants further research.

摘要

目的

观察性研究表明糖尿病与前列腺癌风险降低相关。我们旨在利用英国全科医生研究数据库评估这种关联。

方法

基于人群的病例对照研究嵌套于队列研究中。

结果

我们在1995年1月至2001年12月期间确定了2183例前列腺癌新发病例。我们发现糖尿病患者患前列腺癌的风险降低（比值比=0.72；95%可信区间：0.59 - 0.87）。这种关联在接受治疗的糖尿病患者中观察到（比值比=0.63；95%可信区间：0.50 - 0.80），但在未接受治疗的糖尿病患者中未观察到（比值比=1.01；95%可信区间：0.73 - 1.40）。我们的结果表明，观察到的风险降低可能仅限于胰岛素或磺脲类药物使用者。