糖尿病与前列腺癌风险——一项系统评价与荟萃分析
Diabetes Mellitus and Prostate Cancer Risk-A Systematic Review and Meta-Analysis.
作者信息
Drab Agnieszka, Wdowiak Krystian, Kanadys Wiesław, Zajączkowski Krzysztof, Koczkodaj Paweł, Religioni Urszula, Borowska Mariola, Łoś Magdalena, Lozano-Lorca Macarena
机构信息
Chair of Preclinical Sciences, Department of Medical Informatics and Statistics, Medical University of Lublin, 20-090 Lublin, Poland.
Faculty of Medicine, Medical University of Lublin, K. Jaczewskiego 5 Street, 20-090 Lublin, Poland.
出版信息
Cancers (Basel). 2024 Nov 29;16(23):4010. doi: 10.3390/cancers16234010.
INTRODUCTION
Prostate cancer is the second most commonly diagnosed malignant tumor worldwide and poses a significant challenge to public health. This systematic review and meta-analysis aims to investigate the association between diabetes mellitus and the risk of developing prostate cancer.
METHODS
We conducted a search of PubMed, Embase, and the Cochrane Library from 1998 to 2024. The risk of bias within the included studies was assessed using the Newcastle-Ottawa Scale. The DerSimonian-Laird random-effect model was employed for the meta-analysis. Heterogeneity was evaluated using a forest plot and statistically assessed via the Q test, I index, and -values.
RESULTS
Forty-three studies involving a total of 3,746,769 patients were included. Both case-control (pOR = 0.68, 95% CI: 0.61-0.97; I = 92.24%) and cohort studies (pRR = 0.71, 95% CI: 0.59-0.99; I = 85.41%) suggest that diabetes mellitus is associated with a reduced risk of prostate cancer, though with significant heterogeneity ( < 0.05). Subgroup analysis revealed that the risk of developing prostate cancer was significantly higher in patients with a family history of prostate cancer (pRR = 1.25, 95% CI: 1.16-1.35; I = 69.51%).
CONCLUSIONS
Our meta-analysis of recent observational studies indicates that diabetes mellitus is associated with a reduced risk of developing prostate cancer.
引言
前列腺癌是全球第二常见的恶性肿瘤，对公众健康构成重大挑战。本系统评价和荟萃分析旨在研究糖尿病与患前列腺癌风险之间的关联。
方法
我们检索了1998年至2024年的PubMed、Embase和Cochrane图书馆。使用纽卡斯尔-渥太华量表评估纳入研究中的偏倚风险。荟萃分析采用DerSimonian-Laird随机效应模型。使用森林图评估异质性，并通过Q检验、I指数和P值进行统计学评估。
结果
纳入了43项研究，共涉及3,746,769名患者。病例对照研究（pOR = 0.68，95% CI：0.61 - 0.97；I = 92.24%）和队列研究（pRR = 0.71，95% CI：0.59 - 0.99；I = 85.41%）均表明，糖尿病与前列腺癌风险降低相关，尽管存在显著异质性（P < 0.05）。亚组分析显示，有前列腺癌家族史的患者患前列腺癌的风险显著更高（pRR = 1.25，95% CI：1.16 - 1.35；I = 69.51%）。
结论
我们对近期观察性研究的荟萃分析表明，糖尿病与前列腺癌风险降低相关。
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