Yamaguchi Masaki, Maekawa Mio, Nakamura Yoshihisa, Ueda Mikio
Department of Hematology & Immunology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan.
Am J Hematol. 2005 Oct;80(2):124-7. doi: 10.1002/ajh.20383.
We report here a case of blastic natural killer (NK)-cell lymphoma treated successfully with autologous peripheral blood stem-cell transplantation (APBSCT). A 57-year-old man had skin tumors and was diagnosed as having blastic NK-cell lymphoma by tumor biopsy. Skin, lymph nodes, left tonsil, and bone marrow were involved at presentation. Chemotherapy led to complete remission (CR). To sustain CR, the patient underwent high-dose chemotherapy in combination with 12 Gy of total-body irradiation (TBI) followed by autologous peripheral blood stem-cell rescue. He showed rapid recovery of hematopoiesis and could tolerate regimen-related toxicity after APBSCT. He has maintained long-term remission for 20 months after APBSCT. From this case, we concluded that APBSCT with preconditioning by TBI-containing regimens might be a cure-attaining treatment for disseminated blastic NK-cell lymphoma and should be considered as a choice of treatment in cases where no suitable donors for allogeneic transplantation are available.
我们在此报告一例采用自体外周血干细胞移植（APBSCT）成功治疗的母细胞性自然杀伤（NK）细胞淋巴瘤病例。一名57岁男性患有皮肤肿瘤，经肿瘤活检诊断为母细胞性NK细胞淋巴瘤。初诊时皮肤、淋巴结、左侧扁桃体及骨髓均受累。化疗导致完全缓解（CR）。为维持CR，患者接受了大剂量化疗联合12 Gy全身照射（TBI），随后进行自体外周血干细胞救援。APBSCT后他的造血功能迅速恢复，且能够耐受与治疗方案相关的毒性反应。APBSCT后他已维持长期缓解20个月。从该病例中，我们得出结论，含TBI方案预处理的APBSCT可能是播散性母细胞性NK细胞淋巴瘤的一种治愈性治疗方法，在没有合适的异基因移植供者的情况下应被视为一种治疗选择。
