苯妥英钠增强对乙酰氨基酚的肝毒性，导致肝移植。

Potentiation of acetaminophen hepatotoxicity by phenytoin, leading to liver transplantation.

作者信息

Suchin Scott M, Wolf David C, Lee Young, Ramaswamy Gita, Sheiner Patricia A, Facciuto Marcelo, Marvin Michael R, Kim-Schluger Leona, Lebovics Edward

机构信息

Division of Gastroenterology and Hepatobiliary Diseases, Department of Surgery, New York Medical College, Westchester Medical Center, Valhalla, New York, USA.

出版信息

Dig Dis Sci. 2005 Oct;50(10):1836-8. doi: 10.1007/s10620-005-2947-4.

DOI:10.1007/s10620-005-2947-4

PMID:16187183

Abstract

We report the case of a 22-year-old man who developed fulminant hepatic failure 3 days after an intentional acetaminophen overdose. The patient had a history of a seizure disorder for which he was taking phenytoin. The acetaminophen level at presentation was in the "nontoxic" range. Emergent liver transplantation was performed 4 days after the ingestion. This is the first reported case of successful liver transplantation for acetaminophen-induced fulminant hepatic failure in the setting of phenytoin therapy.

摘要

我们报告了一例22岁男性病例，该患者在故意过量服用对乙酰氨基酚3天后出现暴发性肝衰竭。患者有癫痫病史，正在服用苯妥英钠。就诊时对乙酰氨基酚水平处于“无毒”范围。摄入药物4天后进行了紧急肝移植。这是首例报道的在苯妥英治疗情况下成功进行肝移植治疗对乙酰氨基酚所致暴发性肝衰竭的病例。