Namendys-Silva Silvio Antonio, Posadas-Calleja Juan Gabriel
* División de Medicina Crítica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán.
Rev Invest Clin. 2005 May-Jun;57(3):473-80.
Mechanical ventilation plays a central role in the critical care setting; but its use is closely related with some life threatening complications as nosocomial pneumonia and low cardiac performance. One of the most severe complications is called ventilator-associated lung injury (VALI) and it includes: Barotrauma, volutrauma, atelectrauma, biotrauma and oxygen-mediated toxic effects and it is related with an inflammatory response secondary to the stretching and recruitment process of alveoli within mechanical ventilation. The use of some protective ventilatory strategies has lowered the mortality rate 10% approximately.
机械通气在重症监护环境中起着核心作用；但其使用与一些危及生命的并发症密切相关，如医院获得性肺炎和心功能低下。最严重的并发症之一称为呼吸机相关性肺损伤（VALI），它包括：气压伤、容积伤、肺不张伤、生物伤和氧介导的毒性作用，并且它与机械通气过程中肺泡伸展和复张过程继发的炎症反应有关。采用一些保护性通气策略已使死亡率降低了约10%。
