Feng Chao, Li Han-zhong, Yan Wei-gang, Luo Yu-feng, Cao Jin-ling
Department of Urology, Fuxing Hospital, Capital Medical University, Beijing 100038, China.
Zhonghua Zhong Liu Za Zhi. 2005 Aug;27(8):486-8.
To investigate the expression of chromogranin A (CgA) and synaptophysin (Syn) for differential diagnosis of different kinds of adrenal gland tumors.
The samples of 69 adrenal gland tumors and 4 normal adrenal glands were immunohistochemically analyzed for the expression of chromogranin A and synaptophysin. The statistical analysis of the data was performed using chi-square test.
In the normal adrenal gland, CgA and Syn was exclusively detected in the medulla. CgA was detected in all pheochromocytomas 25/25 (100%), and gave less or no expression in adrenocortical tumors. Syn was detected in adrenocortical adenomas 27/28 (96.4%), adrenocortical carcinoma 7/8 (87.5%), pheochromocytoma 24/25 (96.0%) and adrenal metastatic carcinoma 6/8 (75.0%), respectively.
There is statistically significant difference of CgA expression between adrenalcortical and adrenal medullary tumors, and also between benign and malignant pheochromocytomas. CgA and Syn are immunohistochemically reliable markers in the differential diagnosis of various kinds of adrenal gland tumors.
研究嗜铬粒蛋白A（CgA）和突触素（Syn）的表达，用于不同类型肾上腺肿瘤的鉴别诊断。
对69例肾上腺肿瘤样本和4例正常肾上腺组织进行免疫组织化学分析，检测嗜铬粒蛋白A和突触素的表达。采用卡方检验对数据进行统计学分析。
在正常肾上腺组织中，CgA和Syn仅在髓质中检测到。在所有嗜铬细胞瘤（25/25，100%）中均检测到CgA，而在肾上腺皮质肿瘤中表达较少或无表达。Syn分别在肾上腺皮质腺瘤（27/28，96.4%）、肾上腺皮质癌（7/8，87.5%）、嗜铬细胞瘤（24/25，96.0%）和肾上腺转移癌（6/8，75.0%）中检测到。
肾上腺皮质肿瘤与肾上腺髓质肿瘤之间以及良性与恶性嗜铬细胞瘤之间CgA表达存在统计学差异。CgA和Syn是免疫组织化学鉴别各类肾上腺肿瘤的可靠标志物。
