Rajak K K, Sreenivasa B P, Hosamani M, Singh R P, Singh S K, Singh R K, Bandyopadhyay S K
Division of Virology, Indian Veterinary Research Institute (IVRI), Mukteswar Campus, Nainital (Uttaranchal) 263138, India.
Comp Immunol Microbiol Infect Dis. 2005 Jul;28(4):287-96. doi: 10.1016/j.cimid.2005.08.002. Epub 2005 Sep 26.
Effect of virulent and attenuated peste des petits ruminants (PPR) virus on the immune response to nonspecific antigen (ovalbumin) was investigated. Clinical and serological responses were monitored in goats administered with ovalbumin concurrently with either PPR vaccine or virulent virus. Study showed that PPR virulent virus causes marked immunosuppression as evidenced by leukopenia, lymphopenia, and reduced early antibody response to both specific and nonspecific antigen. These observations were predominant particularly during acute phase of disease (4-10 days post-infection). On the other hand, the vaccine virus induced only a transient lymphopenia without significantly affecting the immune response to nonspecific antigen or to itself during this period. Further, the antibody levels to ovalbumin in the group administered with virulent PPRV increased significantly between days 28 and 35 post-infection in comparison to the titers in other two groups given with either ovalbumin alone or in combination with vaccine.
研究了强毒和弱毒小反刍兽疫（PPR）病毒对非特异性抗原（卵清蛋白）免疫反应的影响。在同时接种卵清蛋白和PPR疫苗或强毒病毒的山羊中监测临床和血清学反应。研究表明，PPR强毒病毒可导致明显的免疫抑制，表现为白细胞减少、淋巴细胞减少，以及对特异性和非特异性抗原的早期抗体反应降低。这些观察结果在疾病急性期（感染后4 - 10天）尤为明显。另一方面，疫苗病毒在此期间仅引起短暂的淋巴细胞减少，而对非特异性抗原或其自身的免疫反应无显著影响。此外，与单独接种卵清蛋白或与疫苗联合接种的其他两组相比，接种强毒PPRV组在感染后第28天至35天期间，针对卵清蛋白的抗体水平显著升高。
