Zhang Rui, Hu Zhanying, Wei Dingcheng, Li Ruizhe, Li Yanmin, Zhang Zhidong
College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu, Sichuan, China.
Front Vet Sci. 2024 May 15;11:1383927. doi: 10.3389/fvets.2024.1383927. eCollection 2024.
Peste des petits ruminants virus (PPRV) is a morbillivirus that causes the acute and highly pathogenic infectious disease peste des petits ruminants (PPR) in small ruminants and poses a major threat to the goat and sheep industries. Currently, there is no effective treatment for PPRV infection. Here, we propose Carboplatin, a platinum-based regimen designed to treat a range of malignancies, as a potential antiviral agent. We showed that Carboplatin exhibits significant antiviral activity against PPRV in a cell culture model. The mechanism of action of Carboplatin against PPRV is mainly attributed to its ability to block STING mediated autophagy. Together, our study supports the discovery of Carboplatin as an antiviral against PPRV and potentially other closely related viruses, sheds light on its mode of action, and establishes STING as a valid and attractive target to counteract viral infection.
小反刍兽疫病毒（PPRV）是一种麻疹病毒，可在小反刍动物中引发急性高致病性传染病小反刍兽疫（PPR），对山羊和绵羊产业构成重大威胁。目前，尚无针对PPRV感染的有效治疗方法。在此，我们提出将卡铂（一种用于治疗多种恶性肿瘤的铂类疗法）作为一种潜在的抗病毒药物。我们发现卡铂在细胞培养模型中对PPRV表现出显著的抗病毒活性。卡铂对PPRV的作用机制主要归因于其阻断STING介导的自噬的能力。总之，我们的研究支持将卡铂作为一种抗PPRV及潜在其他密切相关病毒的抗病毒药物的发现，阐明了其作用方式，并确立STING作为对抗病毒感染的有效且有吸引力的靶点。
