Fjaertoft Gustav, Foucard Tony, Xu Shengyuan, Venge Per
Department of Women's and Children's Health, University of Uppsala, Uppsala, Sweden.
Acta Paediatr. 2005 Jun;94(6):661-6. doi: 10.1111/j.1651-2227.2005.tb01961.x.
To study the changes in blood of human neutrophil lipocalin (HNL) and C-reactive protein (CRP) during the course of an acute infection in children.
Children (n=92) hospitalized with symptoms and signs of acute infections were included and categorized into five groups, i.e. bacterial infection, suspected bacterial infection, viral infection, suspected viral infection and others. Blood was taken at admittance and the following 3-4 d for the measurement of CRP and HNL.
Both CRP and HNL were significantly raised at admittance in bacterial infection as compared to viral infection (p<0.001). After 25-48 h, 83% of the children with bacterial infections still had raised CRP levels in contrast to 11% having raised HNL levels. The levels of CRP, but not those of HNL, were significantly correlated to days of symptoms before admission.
HNL is a promising diagnostic tool in the distinction of acute infections caused by bacteria or virus. The differences in the kinetics of CRP and HNL make HNL a better marker for monitoring antibacterial treatment, since HNL is probably elevated only when an active bacterial infection is at hand.
研究儿童急性感染过程中人类中性粒细胞脂质运载蛋白（HNL）和C反应蛋白（CRP）的血液变化。
纳入92例有急性感染症状和体征的住院儿童，并分为五组，即细菌感染、疑似细菌感染、病毒感染、疑似病毒感染及其他。入院时及随后3 - 4天采集血液，检测CRP和HNL。
与病毒感染相比，细菌感染患儿入院时CRP和HNL均显著升高（p<0.001）。25 - 48小时后，83%的细菌感染患儿CRP水平仍升高，相比之下，11%的患儿HNL水平升高。CRP水平与入院前症状天数显著相关，而HNL水平则不然。
HNL是鉴别细菌或病毒引起的急性感染的一种有前景的诊断工具。CRP和HNL动力学的差异使HNL成为监测抗菌治疗的更好标志物，因为HNL可能仅在存在活跃细菌感染时升高。
