Gebbia V, Russo A, Gebbia N, Rausa L, Ingria F, Spatafora G, Zerillo G, Cimino A, Pastorello T, Ferrara P
Section of Oncology, University of Palermo, Italy.
J Cancer Res Clin Oncol. 1992;118(6):458-62. doi: 10.1007/BF01629430.
A group of 60 patients with advanced head/neck cancer were treated with high-dose folinic acid (500 mg/m-2/week-1) plus 5-fluorouracil (400 mg/m-2/week-1 on day 1, and cisplatin (20 mg/m-2/week-1) 24 h after folinic acid infusion was completed. Out of 55 evaluable patients, 10 patients (18%) experienced a complete response with a mean duration of 11.4+ months, 25 patients had a partial response (45%) of 6.7+ months, 6 patients (11%) showed a stabilization of 4.8+ months, and 14 (25%) progressed. The overall response rate was 63.6% (95% confidence limits 56.5%-69.5%). Patients pretreated with radiotherapy had a 67% overall response rate, while those pretreated with chemotherapy showed a 54% overall response rate. All patients with cancer of the oropharynx had a major response, while patients with cancer of the oral cavity had the lowest response rate. The mean survival of patients who attained a complete response was 14.5+ months. Partial responders had a mean survival of 10.6+ months, while patients who progresses survived a mean of 3.6+ months. The treatment has been very well tolerated with few cases of grade 3 gastrointestinal toxicity. Grade 1-2 leukopenia was recorded in 64% of cases, grade 1-2 nausea/vomiting in 85%. In one case therapy was stopped because of persistent diarrhoea.
一组60例晚期头颈部癌患者接受了大剂量亚叶酸（500mg/m²/周⁻¹）加5-氟尿嘧啶（第1天400mg/m²/周⁻¹）治疗，亚叶酸输注完成24小时后给予顺铂（20mg/m²/周⁻¹）。在55例可评估患者中，10例患者（18%）出现完全缓解，平均缓解持续时间为11.4+个月，25例患者部分缓解（45%），缓解持续时间为6.7+个月，6例患者（11%）病情稳定4.8+个月，14例（25%）病情进展。总缓解率为63.6%（95%置信区间56.5%-69.5%）。接受过放疗的患者总缓解率为67%，而接受过化疗的患者总缓解率为54%。所有口咽癌患者均有显著缓解，而口腔癌患者缓解率最低。达到完全缓解的患者平均生存期为14.5+个月。部分缓解者平均生存期为10.6+个月，而病情进展的患者平均生存期为3.6+个月。该治疗耐受性良好，3级胃肠道毒性病例很少。64%的病例记录有1-2级白细胞减少，85%有1-2级恶心/呕吐。有1例患者因持续性腹泻而停止治疗。
