Suppr超能文献

感染猿泡沫病毒的人类的黏膜和全身抗体反应。

Mucosal and systemic antibody responses in humans infected with simian foamy virus.

作者信息

Cummins James E, Boneva Roumiana S, Switzer William M, Christensen Logan L, Sandstrom Paul, Heneine Walid, Chapman Louisa E, Dezzutti Charlene S

机构信息

HIV and Retrovirology Branch, Division of AIDS, STD, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.

出版信息

J Virol. 2005 Oct;79(20):13186-9. doi: 10.1128/JVI.79.20.13186-13189.2005.

DOI:10.1128/JVI.79.20.13186-13189.2005
PMID:16189020
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1235820/
Abstract

Simian foamy virus (SFV) infection and the subsequent immune response are not well characterized. Blood plasma, saliva, and urine were obtained from four humans and nine chimpanzees persistently infected with chimpanzee-type SFV for an unknown length of time. SFV-specific immunoglobulin G (IgG) antibodies, but not IgA antibodies, against the Gag and Bet proteins were detected, by Western blotting, in all sample types from infected humans and chimpanzees. Overall, chimpanzee samples had higher anti-SFV IgG titers than humans. These results provide a first comparative evaluation of SFV-specific host mucosal humoral immunity in infected humans and chimpanzees that is characterized by a predominant IgG response and a virtually absent IgA response.

摘要

猿猴泡沫病毒（SFV）感染及其后续免疫反应尚未得到充分表征。从4名人类和9只黑猩猩身上采集了血浆、唾液和尿液，这些个体持续感染黑猩猩型SFV，感染时间未知。通过蛋白质印迹法在感染人类和黑猩猩的所有样本类型中检测到针对Gag和Bet蛋白的SFV特异性免疫球蛋白G（IgG）抗体，但未检测到IgA抗体。总体而言，黑猩猩样本中的抗SFV IgG滴度高于人类。这些结果首次对感染人类和黑猩猩中SFV特异性宿主黏膜体液免疫进行了比较评估，其特征是主要为IgG反应，而IgA反应几乎不存在。

相似文献

1
Mucosal and systemic antibody responses in humans infected with simian foamy virus.
J Virol. 2005 Oct;79(20):13186-9. doi: 10.1128/JVI.79.20.13186-13189.2005.
2
IgA immunity in HIV type 1-infected chimpanzees. II. Mucosal immunity.
AIDS Res Hum Retroviruses. 1997 Oct 10;13(15):1273-82. doi: 10.1089/aid.1997.13.1273.
3
Quantification of IgA and IgG and specificities of antibodies to viral proteins in parotid saliva at different stages of HIV-1 infection.
Clin Exp Immunol. 1997 Jul;109(1):47-53. doi: 10.1046/j.1365-2249.1997.4261320.x.
4
Analysis of west African hunters for foamy virus infections.
AIDS Res Hum Retroviruses. 1996 Dec 10;12(18):1725-30. doi: 10.1089/aid.1996.12.1725.
5
Frequent simian foamy virus infection in persons occupationally exposed to nonhuman primates.
J Virol. 2004 Mar;78(6):2780-9. doi: 10.1128/jvi.78.6.2780-2789.2004.
6
Antibodies against Gag are diagnostic markers for feline foamy virus infections while Env and Bet reactivity is undetectable in a substantial fraction of infected cats.
Virology. 2006 Feb 20;345(2):502-8. doi: 10.1016/j.virol.2005.10.022. Epub 2005 Nov 16.
7
An Immunodominant and Conserved B-Cell Epitope in the Envelope of Simian Foamy Virus Recognized by Humans Infected with Zoonotic Strains from Apes.
J Virol. 2019 May 15;93(11). doi: 10.1128/JVI.00068-19. Print 2019 Jun 1.
8
Simian foamy virus infections in a baboon breeding colony.
Virology. 2000 Dec 5;278(1):183-93. doi: 10.1006/viro.2000.0649.
9
Simian foamy virus infection by whole-blood transfer in rhesus macaques: potential for transfusion transmission in humans.
Transfusion. 2006 Aug;46(8):1352-9. doi: 10.1111/j.1537-2995.2006.00862.x.
10
Role of neutralizing antibodies in controlling simian foamy virus transmission and infection.
Transfusion. 2010 Jan;50(1):200-7. doi: 10.1111/j.1537-2995.2009.02372.x. Epub 2009 Aug 28.

引用本文的文献

1
Neutralization of zoonotic retroviruses by human antibodies: Genotype-specific epitopes within the receptor-binding domain from simian foamy virus.
PLoS Pathog. 2023 Apr 24;19(4):e1011339. doi: 10.1371/journal.ppat.1011339. eCollection 2023 Apr.
2
Feline Foamy Virus Infection: Characterization of Experimental Infection and Prevalence of Natural Infection in Domestic Cats with and without Chronic Kidney Disease.
Viruses. 2019 Jul 19;11(7):662. doi: 10.3390/v11070662.
3
An Immunodominant and Conserved B-Cell Epitope in the Envelope of Simian Foamy Virus Recognized by Humans Infected with Zoonotic Strains from Apes.
J Virol. 2019 May 15;93(11). doi: 10.1128/JVI.00068-19. Print 2019 Jun 1.
4
Potent neutralizing antibodies in humans infected with zoonotic simian foamy viruses target conserved epitopes located in the dimorphic domain of the surface envelope protein.
PLoS Pathog. 2018 Oct 8;14(10):e1007293. doi: 10.1371/journal.ppat.1007293. eCollection 2018 Oct.
5
Zoonotic infection of Brazilian primate workers with New World simian foamy virus.
PLoS One. 2017 Sep 20;12(9):e0184502. doi: 10.1371/journal.pone.0184502. eCollection 2017.
6
Origin, evolution and innate immune control of simian foamy viruses in humans.
Curr Opin Virol. 2015 Feb;10:47-55. doi: 10.1016/j.coviro.2014.12.003. Epub 2015 Feb 17.
7
Immunising with the transmembrane envelope proteins of different retroviruses including HIV-1: a comparative study.
Hum Vaccin Immunother. 2013 Mar;9(3):462-70. doi: 10.4161/hv.23221. Epub 2012 Dec 18.
8
Molecular ecology and natural history of simian foamy virus infection in wild-living chimpanzees.
PLoS Pathog. 2008 Jul 4;4(7):e1000097. doi: 10.1371/journal.ppat.1000097.

本文引用的文献

1
Naturally acquired simian retrovirus infections in central African hunters.
Lancet. 2004 Mar 20;363(9413):932-7. doi: 10.1016/S0140-6736(04)15787-5.
2
Frequent simian foamy virus infection in persons occupationally exposed to nonhuman primates.
J Virol. 2004 Mar;78(6):2780-9. doi: 10.1128/jvi.78.6.2780-2789.2004.
3
A second immunologic type of simian foamy virus: monkey throat infections and unmasking by both types.
J Infect Dis. 1961 Jul-Aug;109:1-9. doi: 10.1093/infdis/109.1.1.
4
Human infection with foamy viruses.
Curr Top Microbiol Immunol. 2003;277:181-96. doi: 10.1007/978-3-642-55701-9_8.
5
Screening for simian foamy virus infection by using a combined antigen Western blot assay: evidence for a wide distribution among Old World primates and identification of four new divergent viruses.
Virology. 2003 May 10;309(2):248-57. doi: 10.1016/s0042-6822(03)00070-9.
6
Detection of mucosal antibodies in HIV type 1-infected individuals.
AIDS Res Hum Retroviruses. 2002 Nov 20;18(17):1291-300. doi: 10.1089/088922202320886334.
7
Simian foamy virus infection in a blood donor.
Transfusion. 2002 Jul;42(7):886-91. doi: 10.1046/j.1537-2995.2002.00134.x.
8
Cross-species retroviral transmission from macaques to human beings.
Lancet. 2002 Aug 3;360(9330):387-8. doi: 10.1016/S0140-6736(02)09597-1.
9
Human immunodeficiency virus (HIV)-specific antibody in cervicovaginal lavage specimens obtained from women infected with HIV type 1.
Clin Infect Dis. 2002 Sep 1;35(5):611-7. doi: 10.1086/342201. Epub 2002 Aug 7.
10
Lack of simian immunodeficiency virus (SIV) specific IgA response in the intestine of SIV infected rhesus macaques.
Gut. 2002 May;50(5):608-14. doi: 10.1136/gut.50.5.608.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验