Heneine W, Schweizer M, Sandstrom P, Folks T
HIV and Retrovirology Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, Mail Stop G19, Atlanta, GA 30333, USA.
Curr Top Microbiol Immunol. 2003;277:181-96. doi: 10.1007/978-3-642-55701-9_8.
Virtually all nonhuman primate species investigated thus far including prosimians, New World and Old World monkeys and apes all harbor distinct and species-specific clades of simian foamy virus (SFV). However, evidence supporting the existence of a human-specific foamy virus (FV) is not yet available. Early reports describing widespread infection of healthy and sick humans with FV could not be confirmed. In contrast, all FV infections documented in humans are of zoonotic origin and are identified in persons occupationally exposed to nonhuman primates. The introduction of SFV into humans raises several public health questions regarding disease outcomes and potential for human-to-human transmissibility. The available data from a very limited number of SFV-infected humans suggest that these infections are nonpathogenic and are not easily transmissible. Additional studies are needed to better define the prevalence and natural history of SFV in humans.
迄今为止，几乎所有被研究的非人灵长类物种，包括原猴亚目动物、新大陆猴、旧大陆猴和猿类，都携带着独特的、物种特异性的猿猴泡沫病毒（SFV）进化枝。然而，支持人类特异性泡沫病毒（FV）存在的证据尚未可得。早期描述健康人和病人广泛感染FV的报告无法得到证实。相比之下，人类中记录的所有FV感染均源自动物传染，且在职业接触非人灵长类动物的人群中被发现。SFV传入人类引发了一些关于疾病后果和人际传播可能性的公共卫生问题。来自极少量感染SFV的人类的现有数据表明，这些感染无致病性且不易传播。需要更多研究来更好地界定SFV在人类中的流行情况和自然史。
