McLaughlin T, Steinberg B, Christensen B, Law I, Parving A, Friberg L
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts.
J Cereb Blood Flow Metab. 1992 Jul;12(4):535-45. doi: 10.1038/jcbfm.1992.77.
We used changes in regional cerebral blood flow (rCBF) to disclose regions involved in central auditory and language processing in the normal brain. rCBF was quantified with a fast-rotating, single-photon emission computerized tomograph (SPECT) and inhalation of 133Xe. rCBF data were obtained simultaneously from parallel, transverse slices of the brain. The lower slice was positioned to include both Broca's and Wernicke's areas. The upper slice included regions generally regarded by neurobehaviorists as less related to primary auditory or linguistic functions. We presented three types of auditory stimuli to ten healthy, young volunteers: (a) diotically presented Danish speech, (b) dichotic word stimulation, and (c) white noise. Wilcoxon's signed ranks sum test revealed increased rCBF in language-related areas of cortex, viz., Wernicke's area and its right-sided homologous area as well as in Broca's area (left hemisphere), when subjects listened to narrative speech, compared to white noise (baseline). No significant rCBF differences were detected with this test during dichotic stimulation vs. white noise. A more sophisticated statistical method (factor analysis) disclosed patterns of functionally intercorrelated regions. The factor analysis reduced the highly intercorrelated rCBF measures from 28 regions of interest to a set of three independent factors. These factors accounted for 77% of the total variation in rCBF values. These three factors appeared to represent statistical analogues of independent brain networks involved in (I) auditory/linguistic, (II) attentional, and (III) visual imaging activity.
我们利用局部脑血流量（rCBF）的变化来揭示正常大脑中参与中枢听觉和语言处理的区域。通过快速旋转的单光子发射计算机断层扫描仪（SPECT）和吸入133Xe对rCBF进行定量。从大脑的平行横向切片中同时获取rCBF数据。下部切片的位置包括布洛卡区和韦尼克区。上部切片包括神经行为学家普遍认为与初级听觉或语言功能关系较小的区域。我们向10名健康的年轻志愿者呈现了三种类型的听觉刺激：（a）双耳呈现的丹麦语语音，（b）双耳分听单词刺激，以及（c）白噪声。威尔科克森符号秩和检验显示，与白噪声（基线）相比，当受试者听叙述性语音时，大脑皮层与语言相关区域，即韦尼克区及其右侧同源区域以及布洛卡区（左半球）的rCBF增加。在双耳分听刺激与白噪声对比过程中，该检验未检测到显著的rCBF差异。一种更复杂的统计方法（因子分析）揭示了功能上相互关联区域的模式。因子分析将来自28个感兴趣区域的高度相互关联的rCBF测量值减少为一组三个独立因子。这些因子占rCBF值总变异的77%。这三个因子似乎代表了参与（I）听觉/语言、（II）注意力和（III）视觉成像活动的独立脑网络的统计类似物。
