Pandey Chandra Kant, Singhal Vinay, Kumar Mukesh, Lakra Archana, Ranjan Rajeev, Pal Rashmi, Raza Mehdi, Singh Uttam, Singh Prabhat Kumar
Department of Anaesthesiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow 226014, India.
Can J Anaesth. 2005 Oct;52(8):827-31. doi: 10.1007/BF03021777.
We investigated the effects of pre-incision and post-incision administration of gabapentin on postoperative pain and fentanyl consumption associated with open donor nephrectomy.
Sixty ASA I subjects were randomly allocated into three groups to receive gabapentin 600 mg two hours before surgery and placebo after surgical incision (pre-incision group), placebo two hours before surgery and gabapentin 600 mg after surgical incision (post-incision group), or placebo two hours before surgery and after surgical incision (placebo group). After surgery, pain was assessed using a visual analogue scale (VAS), (1-10 cm) at time points 0, 6, 12, 18, and 24 hr. Subjects received patient-controlled-analgesia (fentanyl 1.0 microg x kg(-1) subject activated dose). Total fentanyl consumption in each group was recorded.
Subjects of pre-incision and post-incision groups had lower VAS scores at all time points (3.1 +/- 1.8, 2.9 +/- 1.3, 2.8 +/- 1.3, 2.5 +/- 0.9, 2.5 +/- 1.5 and 3.6 +/- 1.1, 3.0 +/- 1.2, 3.2 +/- 1.1, 2.9 +/- 1.0, 2.6 +/- 2.2) compared to placebo group (6.6 +/- 1.3, 5.0 +/- 1.0, 4.4 +/- 0.7, 4.2 +/- 0.8, 3.9 +/- 1.0). They also used less fentanyl (563.3 microg +/- 252.8 and 624.0 microg +/- 210.5 respectively) compared to placebo (924.7 microg +/- 417.5), (P < 0.05). No difference in total fentanyl consumption and pain scores at any time points were observed between pre- and post-incision groups.
Pre-incision administration of 600 mg gabapentin has no added benefit over post-incision administration in terms of pain scores and fentanyl consumption in subjects undergoing open donor nephrectomy.
我们研究了术前及术后给予加巴喷丁对开放性供肾肾切除术术后疼痛及芬太尼用量的影响。
60例美国麻醉医师协会（ASA）分级为I级的受试者被随机分为三组，分别在手术前两小时接受600毫克加巴喷丁并在手术切口后接受安慰剂（术前组）、手术前两小时接受安慰剂并在手术切口后接受600毫克加巴喷丁（术后组）或手术前两小时及手术切口后均接受安慰剂（安慰剂组）。术后，在0、6、12、18和24小时时间点使用视觉模拟评分法（VAS，1 - 10厘米）评估疼痛。受试者接受患者自控镇痛（芬太尼1.0微克×千克⁻¹受试者启动剂量）。记录每组的芬太尼总用量。
与安慰剂组（6.6±1.3、5.0±1.0、4.4±0.7、4.2±0.8、3.9±1.0）相比，术前组和术后组受试者在所有时间点的VAS评分均较低（分别为3.1±1.8、2.9±1.3、2.8±1.3、2.5±0.9、2.5±1.5和3.6±1.1、3.0±1.2、3.2±1.1、2.9±1.0、2.6±2.2）。他们的芬太尼用量也比安慰剂组少（分别为563.3微克±252.8和624.0微克±210.5），而安慰剂组为924.7微克±417.5，（P<0.05）。术前组和术后组在任何时间点的芬太尼总用量和疼痛评分均未观察到差异。
对于接受开放性供肾肾切除术的受试者，在疼痛评分和芬太尼用量方面，术前给予600毫克加巴喷丁并不比术后给予更具优势。
