Moonis Gul, Dyce Orville, Loevner Laurie A, Mirza Natasha
Department of Radiology, Hospital of the University of Pennsylvania, 5 Ravdin, 3400 Spruce St, Philadelphia, PA 19104, USA.
Ann Otol Rhinol Laryngol. 2005 Aug;114(8):593-8. doi: 10.1177/000348940511400803.
This study was conducted to evaluate magnetic resonance imaging (MRI) as an objective measure of survival of micronized acellular human dermal graft (Cymetra, LifeCell Corporation) injected into the thyroarytenoid muscle for augmentation of unilateral vocal fold paralysis.
We performed a retrospective review of MRI scans obtained in 6 patients in whom Cymetra was injected into the thyroarytenoid muscle. Gadolinium-enhanced MRI of the larynx was performed 3 days, 1 month, 8 months, 11 months, 15 months, and 21 months after injection. The survival of injected Cymetra was assessed according to information obtained from the MRI scan. Images were also obtained for 1 cm3 of reconstituted Cymetra paste.
The identification of Cymetra in the larynx is based on its proteinaceous content. T1-weighted images of the injected material in the true vocal fold showed hyperintense foci corresponding to injected Cymetra. Hyperintense signal was also present on the T2-weighted images. Persistence of the injected Cymetra was readily detectable by MRI for as long as 11 months.
Cymetra is a viable treatment option for vocal fold augmentation. The duration of survival of Cymetra (as long as 11 months) makes it a good option in cases in which longer survival of the injectable material is needed.
本研究旨在评估磁共振成像（MRI）作为一种客观测量方法，用于评估注射入甲杓肌以改善单侧声带麻痹的微粉化脱细胞人真皮移植物（Cymetra，LifeCell公司）的存留情况。
我们对6例将Cymetra注射入甲杓肌的患者的MRI扫描结果进行了回顾性分析。在注射后3天、1个月、8个月、11个月、15个月和21个月进行钆增强喉部MRI检查。根据MRI扫描获得的信息评估注射的Cymetra的存留情况。还获取了1立方厘米重组Cymetra糊剂的图像。
喉部Cymetra的识别基于其蛋白质含量。真声带中注射材料的T1加权图像显示与注射的Cymetra相对应的高强度病灶。T2加权图像上也出现高强度信号。MRI很容易检测到注射的Cymetra长达11个月的存留情况。
Cymetra是声带增厚的一种可行治疗选择。Cymetra的存留时间（长达11个月）使其成为需要可注射材料更长存留时间的病例的良好选择。
