Czarnecki Marcin, Inglot Małgorzata, Małyszczak Krzysztof, Rymer Weronika, Jańczak Grazyna, Pawłowski Tomasz, Gładysz Andrzej
Katedra i Klinika Chorób Zakaźnych, Chorób Watroby i Nabytych Niedoborów Odpornościowych AM we Wrocławiu.
Przegl Epidemiol. 2005;59(2):431-8.
Neuropsychiatric symptoms are commonly associated with chronic hepatitis C virus infection and its treatment. There are no Polish studies concerned this problem in patients during combination therapy (interferon and ribavirin).
to examine the mood disorders an quality of life during the first 12 weeks of therapy.
The following research instruments were used: the Present State Examination (PSE), The Beck Depression Inventory, The Montgomery Asberg Depression Rating Scale, SF-36, Hamilton Depression Rating Scale. ALT, AST, GGT activity, HCV viral load and genotype, histological activity index of the liver was also measured.
A group of 94 untreated patients (M=, K=) with hepatitis C was examined. 44 of them was examined secondly after 12 week of combination therapy. Depression disorders was observed in 4% pts before treatment and in 11% after 12 weeks therapy. In the group untreated patients there was two statistically significant correlations: between examined neuropsychiatric disorders and HCV viral load and necroinflammatory activity in the liver.
The mood disorders are not so common in the patients with hepatitis C and could have biological etiology. The interferon based therapy increase the frequency and intensity of them.
神经精神症状通常与慢性丙型肝炎病毒感染及其治疗相关。在波兰，尚无关于联合治疗（干扰素和利巴韦林）期间患者这一问题的研究。
研究治疗前12周期间的情绪障碍和生活质量。
使用了以下研究工具：现状检查（PSE）、贝克抑郁量表、蒙哥马利-阿斯伯格抑郁评定量表、SF-36、汉密尔顿抑郁评定量表。还测量了谷丙转氨酶（ALT）、谷草转氨酶（AST）、γ-谷氨酰转移酶（GGT）活性、丙型肝炎病毒载量和基因型以及肝脏组织学活性指数。
对一组94例未经治疗的丙型肝炎患者（男性=，女性=）进行了检查。其中44例在联合治疗12周后进行了二次检查。治疗前4%的患者观察到抑郁障碍，治疗12周后为11%。在未经治疗的患者组中，存在两个统计学上显著的相关性：所检查的神经精神障碍与丙型肝炎病毒载量以及肝脏坏死性炎症活动之间。
情绪障碍在丙型肝炎患者中并不常见，可能有生物学病因。基于干扰素的治疗会增加其发生率和严重程度。
