Simons A D, Thase M E
Department of Psychology, University of Oregon, Eugene 97403.
J Consult Clin Psychol. 1992 Jun;60(3):392-401. doi: 10.1037//0022-006x.60.3.392.
Although there are now considerable data attesting to the efficacy of several forms of treatment for depression, there is surprisingly little information to guide the selection of the treatment most likely to benefit a given patient. Biologic markers of depression have received much attention for their potential to provide theoretically and clinically meaningful subgroups for specific treatments. The relationship between electroencephalographic (EEG) sleep disturbances, treatment outcome, and 1-year follow-up was examined for a sample of 53 patients with endogenous major depression receiving cognitive-behavioral therapy. Overall, there was little support for the prediction of a difference in short- or long-term outcome between patients with and without EEG sleep disturbances.
尽管目前有大量数据证明几种治疗抑郁症的方法是有效的，但令人惊讶的是，几乎没有信息可指导选择最有可能使特定患者受益的治疗方法。抑郁症的生物标志物因其有可能为特定治疗提供理论和临床意义上的亚组而备受关注。对53名接受认知行为疗法的内源性重度抑郁症患者的样本，研究了脑电图（EEG）睡眠障碍、治疗结果和1年随访之间的关系。总体而言，几乎没有证据支持预测有或没有EEG睡眠障碍的患者在短期或长期结果上存在差异。
