The effects of perioperative pain management techniques on food consumption and body weight after laparotomy in rats.
作者信息
Shavit Yehuda, Fish Gila, Wolf Gilly, Mayburd Eduard, Meerson Ylia, Yirmiya Raz, Beilin Benzion
机构信息
*Department of Psychology, Hebrew University, Jerusalem; and †Department of Anesthesiology, Rabin Medical Center, Golda-Hasharon Campus, Petah Tiqva, affiliated with the Sackler School of Medicine, Tel-Aviv University, Israel.
出版信息
Anesth Analg. 2005 Oct;101(4):1112-1116. doi: 10.1213/01.ane.0000167771.98680.a7.
UNLABELLED
We examined the effects of two perioperative pain management techniques on recovery after laparotomy, as assessed by body weight (BW) and food consumption (FC). All rats received a preoperative intrathecal mixture of morphine plus bupivacaine combined with one of two treatments: (a) injection of slow-release morphine at the end of the surgery or (b) an antiinflammatory drug, interleukin-1 receptor antagonist (IL-1ra), combined with the preoperative mixture. Laparotomy significantly decreased FC and BW. Both analgesic treatments resulted in a faster recovery of FC and BW. This beneficial effect was more pronounced in the group receiving preoperative analgesics combined with IL-1ra.
IMPLICATIONS
Effective perioperative pain management can improve postoperative recovery. We studied the effects of two preoperative pain management techniques on recovery after laparotomy in rats. Both analgesic treatments resulted in a faster recovery, especially preoperative analgesics combined with interleukin-1 receptor antagonist.
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