Cooper E L, Roch P
Department of Anatomy and Cell Biology, School of Medicine, University of California, Los Angeles 90024.
J Invertebr Pathol. 1992 Jul;60(1):59-63. doi: 10.1016/0022-2011(92)90154-v.
Earthworms (Lumbricus terrestris) were maintained at 15 degrees C and exposed on filter paper to 10 micrograms/cm2 of the polychlorinated biphenyl (PCB) Aroclor 1254 for 5 days prior to surgical treatments which consisted of wounds, autografts, and allografts. At 1 day after surgery, we observed a higher percentage of healing defects and a significantly greater number of early signs of allograft rejection in exposed worms. Observations for 25 days post-transplantation revealed no response to autografts, but an acceleration of the allograft rejection process in exposed earthworms. We postulate that Aroclor modified host coelomocytes and/or their interactions associated with antigen recognition and inflammation.
将蚯蚓（陆正蚓）饲养在15摄氏度的环境中，并在手术处理（包括创伤、自体移植和异体移植）前5天，将其置于滤纸上，使其接触每平方厘米10微克的多氯联苯（PCB）Aroclor 1254。在手术后1天，我们观察到，暴露组蚯蚓的愈合缺陷百分比更高，异体移植排斥反应的早期迹象数量显著更多。移植后25天的观察结果显示，自体移植无反应，但暴露组蚯蚓的异体移植排斥过程加速。我们推测，Aroclor改变了宿主体腔细胞和/或它们与抗原识别和炎症相关的相互作用。
