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本文引用的文献

1
[Effect of alendronate on periprosthetic bone loss after cemented primary total hip arthroplasty: a prospective randomized study].[阿仑膦酸钠对初次骨水泥型全髋关节置换术后假体周围骨丢失的影响：一项前瞻性随机研究]
Rev Chir Orthop Reparatrice Appar Mot. 2003 Nov;89(7):593-8.
2
Cyclic therapy with etidronate has a therapeutic effect against local osteoporosis after cementless total hip arthroplasty.依替膦酸的循环疗法对非骨水泥型全髋关节置换术后的局部骨质疏松具有治疗作用。
Bone. 2003 Jul;33(1):144-9. doi: 10.1016/s8756-3282(03)00085-1.
3
Periprosthetic bone loss after cemented total hip arthroplasty: a prospective 5-year dual energy radiographic absorptiometry study of 15 patients.骨水泥型全髋关节置换术后假体周围骨丢失：15例患者的前瞻性5年双能X线吸收法研究
Acta Orthop Scand. 2003 Feb;74(1):31-6. doi: 10.1080/00016470310013617.
4
Alendronate reduces periprosthetic bone loss after uncemented primary total hip arthroplasty: a prospective randomized study.阿仑膦酸盐可减少初次非骨水泥型全髋关节置换术后假体周围骨丢失：一项前瞻性随机研究。
J Bone Miner Res. 2001 Nov;16(11):2126-31. doi: 10.1359/jbmr.2001.16.11.2126.
5
Monitoring of periprosthetic BMD after uncemented total hip arthroplasty with dual-energy X-ray absorptiometry--a 3-year follow-up study.使用双能X线吸收法监测非骨水泥型全髋关节置换术后假体周围骨密度——一项3年随访研究。
J Bone Miner Res. 2001 Jun;16(6):1056-61. doi: 10.1359/jbmr.2001.16.6.1056.
6
A meta-analysis of etidronate for the treatment of postmenopausal osteoporosis.依替膦酸治疗绝经后骨质疏松症的荟萃分析。
Osteoporos Int. 2001;12(2):140-51. doi: 10.1007/s001980170147.
7
Measuring bone mineral density of the pelvis and proximal femur after total hip arthroplasty.全髋关节置换术后骨盆及股骨近端骨密度的测量
J Bone Joint Surg Br. 2001 Mar;83(2):283-8. doi: 10.1302/0301-620x.83b2.10562.
8
Effect of pamidronate in preventing local bone loss after total hip arthroplasty: a randomized, double-blind, controlled trial.帕米膦酸盐预防全髋关节置换术后局部骨质流失的效果：一项随机、双盲、对照试验。
J Bone Miner Res. 2001 Mar;16(3):556-64. doi: 10.1359/jbmr.2001.16.3.556.
9
Multinational, placebo-controlled, randomized trial of the effects of alendronate on bone density and fracture risk in postmenopausal women with low bone mass: results of the FOSIT study. Fosamax International Trial Study Group.阿仑膦酸钠对低骨量绝经后妇女骨密度和骨折风险影响的多中心、安慰剂对照、随机试验：FOSIT研究结果。福善美国际试验研究组
Osteoporos Int. 1999;9(5):461-8. doi: 10.1007/pl00004171.
10
Bisphosphonates: from the laboratory to the clinic and back again.双膦酸盐：从实验室到临床再回归实验室
Bone. 1999 Jul;25(1):97-106. doi: 10.1016/s8756-3282(99)00116-7.

依替膦酸并不抑制骨水泥型髋关节置换术后假体周围骨质流失。

Etidronate does not suppress periprosthetic bone loss following cemented hip arthroplasty.

作者信息

Fokter S K, Komadina R, Repse-Fokter A, Yerby S A, Kocijancic A, Marc J

机构信息

Department of Orthopaedic Surgery and Sports Trauma, Celje General Hospital, Oblakova 5, 3000, Celje, Slovenia.

出版信息

Int Orthop. 2005 Dec;29(6):362-7. doi: 10.1007/s00264-005-0018-2. Epub 2005 Sep 29.

DOI:10.1007/s00264-005-0018-2
PMID:16193347
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2231584/
Abstract

Periprosthetic bone loss after arthroplasty may threaten prosthesis survival. The current study investigated the effect of etidronate therapy on periprosthetic, contralateral hip, and spine bone mineral density (BMD) in a one-year, prospective, randomized, double-blind study on 46 patients after cemented hip arthroplasty. BMD was measured with dual-energy X-ray absorptiometry (DXA). There were no significant differences between mean BMD measurements of the etidronate and placebo groups, with the exception of the mean percent change in the spine at six months and 12 months and in Gruen zone 3 at six months; in all three cases, the etidronate group had significantly greater mean values. These findings suggest that cyclic etidronate therapy has no significant effect in suppressing periprosthetic bone loss following cemented hip arthroplasty.

摘要

关节置换术后假体周围骨丢失可能会威胁假体的使用寿命。本研究在一项为期一年的前瞻性、随机、双盲研究中，对46例接受骨水泥型髋关节置换术的患者，调查了依替膦酸治疗对假体周围、对侧髋关节和脊柱骨密度（BMD）的影响。采用双能X线吸收法（DXA）测量骨密度。依替膦酸组和安慰剂组的平均骨密度测量值之间无显著差异，但在6个月和12个月时脊柱的平均变化百分比以及6个月时Gruen 3区除外；在这三种情况下，依替膦酸组的平均值均显著更高。这些发现表明，周期性依替膦酸治疗在抑制骨水泥型髋关节置换术后假体周围骨丢失方面无显著效果。