Li M, Zhang H, Yang J, Shao J F, Jiang H Y
Laboratory of Immunology, Tongji Medical University, Wuhan.
J Tongji Med Univ. 1992;12(1):39-42. doi: 10.1007/BF02887757.
The interference of Cyclosporin A (CyA) with peripheral lymphocytes DNA synthesis was investigated. The results showed that the drug could strongly inhibit T cell proliferation in response to PHA stimulation if added at the start or at the early phase of the process, and it failed to do so if added 48 h later when most cells had already started to proliferate. Without PHA, no obvious differences were detected between normal control and CyA-treated cells. A comparison was made between T cell DNA synthesis of peripheral blood lymphocytes of healthy volunteers and renal transplant patients. It was found that T-cell DNA synthesis of patients was significantly lower than that of the healthy controls. From the above it may be suggested that CyA activity on T cell proliferation is similar in vivo and in vitro.
研究了环孢素A（CyA）对外周淋巴细胞DNA合成的干扰作用。结果显示，如果在该过程开始时或早期添加该药物，它能够强烈抑制T细胞对PHA刺激的增殖反应；而如果在48小时后添加，此时大多数细胞已经开始增殖，则无法抑制。在无PHA的情况下，正常对照细胞和经CyA处理的细胞之间未检测到明显差异。对健康志愿者和肾移植患者外周血淋巴细胞的T细胞DNA合成进行了比较。发现患者的T细胞DNA合成明显低于健康对照组。由此可以推测，CyA对T细胞增殖的作用在体内和体外相似。
Zotero 插件